Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dyphylline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.90 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.90 |
| ▸ | POLB | P06746 | 3/20 | 0.90 |
| ▸ | ADORA2B | P29275 | 5/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | CNR1 | P21554 | 1/20 | 0.62 |
| ▸ | ACHE | P22303 | 1/20 | 0.62 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.62 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.62 |
| ▸ | NTSR1 | P30989 | 1/20 | 0.62 |
| ▸ | MC3R | P41968 | 1/20 | 0.62 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.62 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.62 |
| ▸ | GDA | Q9Y2T3 | 1/20 | 0.62 |
| ▸ | NR2E1 | Q9Y466 | 1/20 | 0.62 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.59 |
| ▸ | GAA | P10253 | 1/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dyphylline SCHEMBL8192 | 0.95 | LMNA (1.00) | LMNASMN1; SMN2POLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL1816552 | 0.95 | LMNA (1.00) | LMNASMN1; SMN2POLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL123781 | 0.95 | LMNA (1.00) | LMNASMN1; SMN2POLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL27937456 | 0.94 | LMNA (0.97) | LMNASMN1; SMN2POLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL28299816 | 0.90 | LMNA (0.90) | LMNASMN1; SMN2POLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL13724353 | 0.90 | LMNA (0.90) | LMNASMN1; SMN2POLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL5198235 | 0.89 | LMNA (0.75) | LMNASMN1; SMN2POLBADORA2BPIK3CD | |
| Dyphylline SCHEMBL9007973 | 0.88 | SMN1; SMN2 (0.86) | LMNASMN1; SMN2POLBADORA2BRXFP1 | |
| SCHEMBL5265296 | 0.85 | LMNA (0.81) | LMNASMN1; SMN2POLBADORA2BRXFP1 | |
| SCHEMBL10063431 | 0.84 | LMNA (0.80) | LMNASMN1; SMN2POLBADORA2BRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1315499-A4 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ANORECTAL DISORDERS | STRAKAN INT LTD (GB) | 2007-09-05 | — | — | EP | disclosed |
| US-20060198883-A1 | Compositions and methods for the treatment of anorectal disorders | CELLEGY PHARMACEUTICALS, INC. (US) | 2006-09-07 | — | — | US | disclosed |
| US-6627632-B2 | Compositions and methods for the treatment of anorectal disorders | CELLEGY PHARMACEUTICALS, INC. | 2003-09-30 | — | — | US | disclosed |
| WO-2003075851-A2 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ANORECTAL DISORDERS | CELLEGY PHARMACEUTICALS, INC. (US) | 2003-09-18 | — | — | WO | disclosed |
| EP-1315499-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ANORECTAL DISORDERS | Cellegy Pharmaceuticals, Inc (US) | 2003-06-04 | — | — | EP | disclosed |
| WO-2002009714-A9 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ANORECTAL DISORDERS | CELLEGY PHARMA INC (US) | 2003-03-06 | — | — | WO | disclosed |
| US-20020187990-A1 | Compositions and methods for the treatment of anorectal disorders | CELLEGY PHARMACEUTICALS, INC. | 2002-12-12 | — | — | US | disclosed |
| US-20020072522-A1 | Compositions and methods for the treatment of anorectal disorders | STRAKAN INTERNATIONAL LIMITED (BM) | 2002-06-13 | — | — | US | disclosed |
| WO-2002009714-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF ANORECTAL DISORDERS | CELLEGY PHARMACEUTICALS, INC. (US) | 2002-02-07 | — | — | WO | disclosed |