Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Dyphylline. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 1.00 |
| ▸ | POLB | P06746 | 2/20 | 1.00 |
| ▸ | ADORA2B | P29275 | 4/20 | 0.68 |
| ▸ | RXFP1 | Q9HBX9 | 4/20 | 0.64 |
| ▸ | GAA | P10253 | 1/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.60 |
| ▸ | MAPT | P10636 | 1/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dyphylline SCHEMBL123781 | 1.00 | LMNA (1.00) | LMNASMN1; SMN2POLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL1816552 | 1.00 | LMNA (1.00) | LMNASMN1; SMN2POLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL27937456 | 0.99 | LMNA (0.97) | LMNASMN1; SMN2POLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL28299816 | 0.95 | LMNA (0.90) | LMNASMN1; SMN2POLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL13724353 | 0.95 | LMNA (0.90) | LMNASMN1; SMN2POLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL5194181 | 0.95 | LMNA (0.90) | LMNASMN1; SMN2POLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL9007973 | 0.93 | SMN1; SMN2 (0.86) | LMNASMN1; SMN2POLBADORA2BRXFP1 | |
| SCHEMBL5265296 | 0.89 | LMNA (0.81) | LMNASMN1; SMN2POLBADORA2BRXFP1 | |
| SCHEMBL10063431 | 0.89 | LMNA (0.80) | LMNASMN1; SMN2POLBADORA2BRXFP1 | |
| Dyphylline SCHEMBL10890402 | 0.89 | LMNA (0.78) | LMNASMN1; SMN2POLBADORA2BRXFP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 10140 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260137082-A1 | FUNGICIDAL COMPOSITIONS COMPRISING FLUDIOXONIL | SYNGENTA CROP PROTECTION AG (CH) | 2026-05-21 | — | — | US | claimed |
| WO-2025244856-A1 | METHODS AND COMPOSITIONS RELATING TO ELQ COMPOUNDS | OREGON HEALTH & SCIENCE UNIVERSITY (US) | 2025-11-27 | — | — | WO | claimed |
| EP-3060043-B1 | PESTICIDAL COMPOSITIONS AND RELATED METHODS | CORTEVA AGRISCIENCE LLC (US) | 2025-11-26 | — | — | EP | claimed |
| US-12471599-B2 | Agricultural compositions comprising remodeled nitrogen fixing microbes | PIVOT BIO, INC. (US) | 2025-11-18 | — | — | US | claimed |
| EP-3578542-B1 | COMPOSITIONS HAVING PESTICIDAL UTILITY AND PROCESSES RELATED THERETO | CORTEVA AGRISCIENCE LLC (US) | 2025-11-12 | — | — | EP | claimed |
| EP-4627920-A1 | BINARY INSECTICIDE COMPOSITION AND USE THEREOF | Shenyang Sinochem Agrochemicals R & D Co., Ltd. (CN) | 2025-10-08 | — | — | EP | claimed |
| EP-3578543-B1 | COMPOSITIONS COMPRISING MOLECULES HAVING PESTICIDAL UTILITY AND PROCESSES RELATED THERETO | CORTEVA AGRISCIENCE LLC (US) | 2025-08-20 | — | — | EP | claimed |
| US-20250185667-A1 | AGRICULTURAL COMPOSITIONS COMPRISING REMODELED NITROGEN FIXING MICROBES | HSBC BANK USA, N.A. | 2025-06-12 | — | — | US | claimed |
| CN-120064547-A | Method for detecting dihydroxypropehylline injection | 上海信谊金朱药业有限公司 | 2025-05-30 | — | — | CN | claimed |
| EP-3578541-B1 | COMPOSITIONS COMPRISING MOLECULES HAVING PESTICIDAL UTILITY, AND PROCESSES RELATED THERETO | CORTEVA AGRISCIENCE LLC (US) | 2025-05-28 | — | — | EP | claimed |
| US-4425346-A | ANTIGLAUCOMA AGENTS | SMITH AND NEPHEW ASSOCIATED COMPANIES LIMITED (GB) | 1984-01-10 | — | — | US | claimed |
| EP-0059524-A1 | Pharmaceutical composition containing aminopteridines or aminopyrimido(4,5-d)pyrimidines | Smith and Nephew Associated Companies p.l.c. (GB) | 1982-09-08 | — | — | EP | claimed |
| US-4348397-A | ENHANCED RETENTION OF ANTIASTHMA AGENT | RESEARCH CORPORATION (US) | 1982-09-07 | — | — | US | claimed |
| US-4341783-A | Topical use of dyphylline and dyphylline containing compositions | LEMMON COMPANY (US) | 1982-07-27 | — | — | US | claimed |
| EP-0045617-A2 | Pharmaceutical composition | Smith and Nephew Associated Companies p.l.c. (GB) | 1982-02-10 | — | — | EP | claimed |
| US-4190419-A | Device for detecting serum bilirubin | MILES LABORATORIES, INC. (US) | 1980-02-26 | — | — | US | claimed |
| US-4119401-A | Total bilirubin assay | TECHNICON INSTRUMENTS CORPORATION (US) | 1978-10-10 | — | — | US | claimed |
| US-4117132-A | PROCESS FOR THE PRODUCTION OF STABILIZED PURE THEOPHYLLINE IN NEUTRAL, AQUEOUS SOLUTION | DR. ADOLF SEEBACH AG (CH) | 1978-09-26 | — | — | US | claimed |
| US-4038031-A | REACTION WITH DIAZONIUM COMPOUND | MILES LABORATORIES, INC. (US) | 1977-07-26 | — | — | US | claimed |
| US-3957995-A | ADMINISTERING, CEREBRAL VASODILATOR ACTIVITY | PARCOR (FR) | 1976-05-18 | — | — | US | claimed |