Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TBXA2R | P21731 | 3/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.38 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 2/20 | 0.36 |
| ▸ | SFRP1 | Q8N474 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10405667 | 0.76 | NR1H2 (0.49) | TBXA2RNR1H2KMT2ATBXAS1MEN1 | |
| SCHEMBL8718069 | 0.74 | ALDH1A1 (0.44) | LMNAALDH1A1RAB9AKMT2ANPC1 | |
| SCHEMBL8715129 | 0.74 | CA1 (0.41) | LMNAALDH1A1NR1H2KMT2AMAPT | |
| SCHEMBL8720077 | 0.71 | KMT2A (0.39) | LMNAALDH1A1NR1H2RAB9AKMT2A | |
| SCHEMBL9383997 | 0.70 | NR1H2 (0.35) | TBXA2RLMNAALDH1A1NR1H2KMT2A | |
| SCHEMBL10405734 | 0.69 | NR1H2 (0.48) | TBXA2RNR1H2TBXAS1SMN1; SMN2 | |
| SCHEMBL10405640 | 0.68 | TBXA2R (0.51) | TBXA2RNR1H2KMT2AMEN1 | |
| SCHEMBL10405894 | 0.68 | CA1 (0.54) | LMNAALDH1A1NR1H2KMT2AMAPT | |
| SCHEMBL10406384 | 0.67 | NR1H2 (0.49) | NR1H2KMT2AMEN1TP53 | |
| SCHEMBL11556100 | 0.66 | ALDH1A1 (0.42) | LMNAALDH1A1RAB9AKMT2ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5739132-A | ENDOTHOXIN SHOCK; NEPHRITIS | TANABE SEIYAKU CO., LTD. (JP) | 1998-04-14 | — | — | US | disclosed |
| EP-0579059-A1 | Pyridazinone derivatives and processes for preparing the same | TANABE SEIYAKU CO., LTD. (JP) | 1994-01-19 | — | — | EP | disclosed |