Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.58 |
| ▸ | MAPT | P10636 | 6/20 | 0.58 |
| ▸ | MEN1 | O00255 | 4/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.56 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | PPIA | P62937 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.52 |
| ▸ | HPGD | P15428 | 2/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6811585 | 0.79 | ALDH1A1 (0.60) | ALDH1A1MAPTMEN1KMT2AALOX15 | |
| SCHEMBL8721765 | 0.78 | MAPT (0.62) | ALDH1A1MAPTGAASMN1; SMN2KDM4E | |
| SCHEMBL8725948 | 0.78 | SMN1; SMN2 (0.64) | ALDH1A1MAPTGAAHPGDSMN1; SMN2 | |
| SCHEMBL6155867 | 0.77 | IDO1 (0.72) | ALDH1A1MAPTMEN1KMT2APPIA | |
| SCHEMBL68180 | 0.77 | MAPT (0.70) | ALDH1A1MAPTMEN1KMT2AALOX15 | |
| SCHEMBL3183964 | 0.77 | ALDH1A1 (0.63) | ALDH1A1MAPTMEN1KMT2AALOX15 | |
| SCHEMBL6814385 | 0.77 | SMN1; SMN2 (0.67) | ALDH1A1MAPTMEN1KMT2APPIA | |
| SCHEMBL11542953 | 0.76 | ALDH1A1 (0.67) | ALDH1A1MAPTMEN1KMT2APPIA | |
| SCHEMBL8910582 | 0.75 | GAA (0.62) | ALDH1A1MAPTMEN1KMT2AMAPK1 | |
| SCHEMBL6811589 | 0.75 | ALDH1A1 (0.62) | ALDH1A1MAPTMEN1KMT2APPIA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876354-A1 | 2-(SUBSTITUTED SULFANYL)-3,5-DIHYDRO-IMIDAZOL-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997019931-A1 | 2-(SUBSTITUTED SULFANYL)-3,5-DIHYDRO-IMIDAZOL-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-06-05 | — | — | WO | disclosed |
| US-5599829-A | FOR INCREASED HIGH DENSITY LIPOPROTEIN LEVELS IN BLOOD | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-02-04 | — | — | US | disclosed |