Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.63 |
| ▸ | NOX1 | Q9Y5S8 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 4/20 | 0.57 |
| ▸ | POLB | P06746 | 2/20 | 0.57 |
| ▸ | ALOX12 | P18054 | 2/20 | 0.57 |
| ▸ | HTT | P42858 | 2/20 | 0.55 |
| ▸ | ALPL | P05186 | 1/20 | 0.55 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.51 |
| ▸ | CDC7 | O00311 | 1/20 | 0.50 |
| ▸ | EEF2K | O00418 | 1/20 | 0.50 |
| ▸ | PLK4 | O00444 | 1/20 | 0.50 |
| ▸ | AURKA | O14965 | 1/20 | 0.50 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.50 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.50 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.50 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8721765 | 0.89 | MAPT (0.62) | SMN1; SMN2MAPTALDH1A1LMNAPOLB | |
| SCHEMBL6097065 | 0.81 | SMN1; SMN2 (0.78) | SMN1; SMN2MAPTALDH1A1NOX1LMNA | |
| SCHEMBL8720682 | 0.80 | POLB (0.67) | MAPTALDH1A1LMNAPOLBALOX12 | |
| SCHEMBL11533572 | 0.80 | SMN1; SMN2 (0.76) | SMN1; SMN2MAPTALDH1A1NOX1LMNA | |
| SCHEMBL8721047 | 0.80 | L3MBTL1 (0.60) | SMN1; SMN2MAPTALDH1A1LMNAPOLB | |
| SCHEMBL11757368 | 0.78 | SMN1; SMN2 (0.78) | SMN1; SMN2MAPTALDH1A1NOX1LMNA | |
| SCHEMBL29048142 | 0.78 | KMT2A (0.59) | SMN1; SMN2MAPTALDH1A1NOX1LMNA | |
| SCHEMBL8720867 | 0.78 | ALDH1A1 (0.58) | SMN1; SMN2MAPTALDH1A1HPGDGAA | |
| SCHEMBL10488934 | 0.77 | MAPT (0.76) | SMN1; SMN2MAPTALDH1A1NOX1LMNA | |
| SCHEMBL6929125 | 0.77 | GAA (0.70) | SMN1; SMN2MAPTALDH1A1NOX1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876354-A1 | 2-(SUBSTITUTED SULFANYL)-3,5-DIHYDRO-IMIDAZOL-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997019931-A1 | 2-(SUBSTITUTED SULFANYL)-3,5-DIHYDRO-IMIDAZOL-4-ONE DERIVATIVES | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-06-05 | — | — | WO | disclosed |
| US-5599829-A | FOR INCREASED HIGH DENSITY LIPOPROTEIN LEVELS IN BLOOD | AMERICAN HOME PRODUCTS CORPORATION (US) | 1997-02-04 | — | — | US | disclosed |