Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | TRPC3 | Q13507 | 1/20 | 0.35 |
| ▸ | TRPC4 | Q9UBN4 | 1/20 | 0.35 |
| ▸ | TRPC5 | Q9UL62 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | UTS2R | Q9UKP6 | 2/20 | 0.32 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.31 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | USP2 | O75604 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | HTR6 | P50406 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | STAT1 | P42224 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8719112 | 0.72 | SMN1; SMN2 (0.33) | BCHETRPC3TRPC4TRPC5ELANE | |
| SCHEMBL8476774 | 0.71 | UTS2R (0.34) | BCHETRPC3TRPC4TRPC5NPC1 | |
| SCHEMBL8716380 | 0.67 | TLR8 (0.34) | BCHETRPC3TRPC4TRPC5NPC1 | |
| SCHEMBL8716298 | 0.64 | MMP3 (0.31) | UTS2RKDM4ENPSR1L3MBTL1 | |
| SCHEMBL648497 | 0.60 | NPC1 (0.50) | NPC1TLR8MAPTALDH1A1STAT1 | |
| SCHEMBL8107641 | 0.57 | HDAC3 (0.46) | BCHETRPC3TRPC4TRPC5NPC1 | |
| SCHEMBL20668001 | 0.57 | ACP1 (0.41) | NPC1TLR8KDM4EUSP2HSD17B10 | |
| SCHEMBL8716334 | 0.57 | LIMK1 (0.31) | ELANE | |
| SCHEMBL181559 | 0.56 | MAPT (0.52) | CYP3A4KCNH2KDM4EMAPTALDH1A1 | |
| SCHEMBL33105 | 0.55 | L3MBTL1 (0.49) | NPC1MAPTALDH1A1STAT1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876379-A1 | FUSED 1,2,4-THIADIAZINE AND FUSED 1,4-THIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997026265-A1 | FUSED 1,2,4-THIADIAZINE AND FUSED 1,4-THIAZINE DERIVATIVES, THEIR PREPARATION AND USE | NOVO NORDISK A/S (DK) | 1997-07-24 | — | — | WO | disclosed |