Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 9/20 | 0.49 |
| ▸ | NPC1 | O15118 | 8/20 | 0.49 |
| ▸ | MAPT | P10636 | 7/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | POLB | P06746 | 3/20 | 0.46 |
| ▸ | MGMT | P16455 | 4/20 | 0.41 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 3/20 | 0.40 |
| ▸ | SETD7 | Q8WTS6 | 1/20 | 0.40 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8722332 | 0.77 | MGMT (0.63) | MAPTKMT2AMGMT | |
| SCHEMBL8508213 | 0.73 | NPC1 (0.47) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL13983985 | 0.70 | GAA (0.55) | RAB9AMAPTKMT2APOLBGAA | |
| SCHEMBL27451660 | 0.68 | KMT2A (0.68) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL11394039 | 0.67 | NPC1 (0.48) | RAB9ANPC1MAPTKMT2APOLB | |
| SCHEMBL6858979 | 0.67 | ALDH1A1 (0.67) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL27612725 | 0.66 | CD274 (0.46) | RAB9ANPC1MAPTSMN1; SMN2ALDH1A1 | |
| SCHEMBL4997847 | 0.66 | MEN1 (0.57) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL27599355 | 0.66 | ALDH1A1 (0.61) | RAB9ANPC1MAPTMEN1KMT2A | |
| SCHEMBL11407579 | 0.65 | LMNA (0.43) | RAB9ANPC1MAPTKMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874848-A1 | PYRIMIDINE DERIVATIVES AND GUANINE DERIVATIVES, AND THEIR USE IN TREATING TUMOUR CELLS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997020843-A1 | PYRIMIDINE DERIVATIVES AND GUANINE DERIVATIVES, AND THEIR USE IN TREATING TUMOUR CELLS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1997-06-12 | — | — | WO | disclosed |