Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MGMT | P16455 | 10/20 | 0.63 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.46 |
| ▸ | CDK2 | P24941 | 1/20 | 0.46 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3309544 | 0.77 | MGMT (1.00) | MGMTCCNA2CDK2CCNA1CYP3A4 | |
| SCHEMBL8722340 | 0.77 | RAB9A (0.49) | MGMTKMT2AMAPT | |
| SCHEMBL8507246 | 0.71 | MGMT (0.65) | MGMTCCNA2CDK2CCNA1KMT2A | |
| SCHEMBL1154297 | 0.70 | DCPS (0.63) | KMT2ATDP1L3MBTL1 | |
| SCHEMBL9392819 | 0.70 | CYP3A4 (0.56) | KMT2ATDP1L3MBTL1CYP3A4MAPT | |
| SCHEMBL18552099 | 0.69 | ALDH1A1 (0.53) | — | |
| SCHEMBL3584203 | 0.68 | KMT2A (0.49) | KMT2ATDP1L3MBTL1CYP3A4MAPT | |
| SCHEMBL1520844 | 0.67 | CYP3A4 (0.60) | KMT2ATDP1L3MBTL1CYP3A4MAPT | |
| SCHEMBL27612725 | 0.67 | CD274 (0.46) | MAPT | |
| SCHEMBL6937625 | 0.67 | MAPT (0.46) | KMT2ATDP1CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874848-A1 | PYRIMIDINE DERIVATIVES AND GUANINE DERIVATIVES, AND THEIR USE IN TREATING TUMOUR CELLS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997020843-A1 | PYRIMIDINE DERIVATIVES AND GUANINE DERIVATIVES, AND THEIR USE IN TREATING TUMOUR CELLS | CANCER RESEARCH CAMPAIGN TECHNOLOGY LIMITED (GB) | 1997-06-12 | — | — | WO | disclosed |