SCHEMBL8722507

SCHEMBL8722507

CC(C)[Si](C)(C)c1cccc(Br)c1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.41
MAPK1 P28482 1/20 0.41
GABRG2 P18507 5/20 0.38
GABRB3 P28472 5/20 0.38
GABRA5 P31644 5/20 0.38
GABRA3 P34903 5/20 0.38
GABRA1 P14867 4/20 0.38
MAOA P21397 1/20 0.37
NPC1 O15118 3/20 0.35
RAB9A P51151 3/20 0.35
SMN1; SMN2 Q16637 3/20 0.35
TP53 P04637 1/20 0.35
TSHR P16473 1/20 0.35
MEN1 O00255 3/20 0.35
KMT2A Q03164 3/20 0.35
GAA P10253 2/20 0.35
KDM4E B2RXH2 1/20 0.35
MAPT P10636 1/20 0.35
NPSR1 Q6W5P4 1/20 0.35
CYP1A2 P05177 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28477358 0.81 ALDH1A1 (0.43) ALDH1A1MAPK1GABRG2GABRB3GABRA5
SCHEMBL2017485 0.79 ALDH1A1 (0.41) ALDH1A1MAPK1GABRG2GABRB3GABRA5
SCHEMBL783254 0.78 ALDH1A1 (0.48) ALDH1A1MAPK1GABRG2GABRB3GABRA5
SCHEMBL29945235 0.78 ALDH1A1 (0.48) ALDH1A1MAPK1GABRG2GABRB3GABRA5
SCHEMBL23457112 0.78 ALDH1A1 (0.48) ALDH1A1MAPK1GABRG2GABRB3GABRA5
SCHEMBL10928549 0.76 ALDH1A1 (0.46) ALDH1A1MAPK1GABRG2GABRB3GABRA5
SCHEMBL23557563 0.72 ESR1 (0.41) MAOATSHRMAPT
SCHEMBL4876931 0.72 ALDH1A1 (0.46) ALDH1A1MAPK1NPC1RAB9ASMN1; SMN2
SCHEMBL8723541 0.71 ALDH1A1 (0.41) ALDH1A1MAPK1GABRG2GABRB3GABRA5
SCHEMBL17937684 0.71 ALDH1A1 (0.41) ALDH1A1MAPK1GABRG2GABRB3GABRA5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5760267-A FROM 1-HALO-3-TRIALKYLSILYLBENZENES HOECHST MARION ROUSSEL INC. (US) 1998-06-02 US disclosed
EP-0833829-A1 A PROCESS FOR PREPARING 1-(3-TRIALKYLSILYLPHENYL)-2,2,2-TRIFLUOROMETHYL ETHANONE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1998-04-08 EP disclosed
EP-0791001-A1 PROCESS FOR THE PREPARATION OF 1-HALO-3-TRIALKYLSILANYL-BENZENE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1997-08-27 EP disclosed
WO-1997000877-A1 A PROCESS FOR PREPARING 1-(3-TRIALKYLSILYLPHENYL)-2,2,2-TRIFLUOROMETHYL ETHANONE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1997-01-09 WO disclosed
EP-0749972-A1 A process for preparing 1-(3-trialkylsilylphenyl)-2,2,2-trifluoromethyl ethanone derivatives MERRELL PHARMACEUTICALS INC. (US) 1996-12-27 EP disclosed
WO-1996014322-A1 PROCESS FOR THE PREPARATION OF 1-HALO-3-TRIALKYLSILANYL-BENZENE DERIVATIVES HOECHST MARION ROUSSEL, INC. (US) 1996-05-17 WO disclosed
US-5486638-A DEHALOGENATION AND FORMATION OF SILYL BOND ON BENZENE RING MARION MERRELL DOW INC. (US) 1996-01-23 US disclosed