SCHEMBL872286

SCHEMBL872286

C=Cc1cnc(C=C)cn1

nearest known ligand 0.37

Predicted protein targets (top 3)

geneUniProtsupporting neighboursconfidence
HDAC8 Q9BY41 1/20 0.37
ALDH1A1 P00352 1/20 0.32
MAPT P10636 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL9797693 0.86 KCNJ1 (0.41) HDAC8
SCHEMBL934260 0.84
SCHEMBL17843148 0.84
SCHEMBL30771589 0.84
SCHEMBL1107417 0.84
SCHEMBL3663922 0.78 TRPV4 (0.39)
SCHEMBL21508908 0.78 KDM4E (0.32) HDAC8
Ligustrazine SCHEMBL29236276 0.76 HDAC8 (0.31) HDAC8
SCHEMBL20920765 0.75
SCHEMBL5042238 0.75 SIRT6 (0.52) ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20130287700-A1 COMPOUNDS FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISORDERS ON THE OLFACTORY EPITHELIUM KLINIKUM DARMSTADT GMBH (DE) 2013-10-31 US claimed
EP-2619591-A2 COMPOUNDS FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISORDERS ON THE OLFACTORY EPITHELIUM Technische Universität Darmstadt (DE) 2013-07-31 EP claimed
EP-2619590-A2 COMPOUNDS FOR DIAGNOSING NEURODEGENERATIVE DISEASES AT THE RETINA Technische Universität Darmstadt (DE) 2013-07-31 EP claimed
WO-2013041522-A1 METHODS AND DEVICES FOR THE DETECTION OF TAU PROTEIN DEPOSITS IN EYES CARL ZEISS AG (DE) 2013-03-28 WO claimed
WO-2012041292-A2 COMPOUNDS FOR DIAGNOSING NEURODEGENERATIVE DISEASES AT THE RETINA KLINIKUM DARMSTADT GMBH (DE) 2012-04-05 WO claimed
WO-2012037928-A2 COMPOUNDS FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISORDERS ON THE OLFACTORY EPITHELIUM KLINIKUM DARMSTADT GMBH (DE) 2012-03-29 WO claimed
CN-1186330-C Polymerizable hydrophilio ultraviolet light absorbing manomers PHARMACIA & UPJOHN BV (NL) 2005-01-26 CN claimed
EP-1077952-B1 POLYMERIZABLE HYDROPHILIC ULTRAVIOLET LIGHT ABSORBING MONOMERS PHARMACIA & UPJOHN BV (NL) 2003-11-12 EP claimed
EP-0889916-B1 HIGH REFRACTIVE INDEX HYDROGELS PREPARED FROM POLYMERS AND COPOLYMERS OF N-BENZYL-N-METHYLACRYLAMIDE UPJOHN CO (US) 2003-05-07 EP claimed
CN-1103786-C High refractive index hydrogels prepared from polymers and copolymers of N-benzyl-N-methylacrylamide PHARMACIA IOVISION INC (US) 2003-03-26 CN claimed
EP-1077952-A1 POLYMERIZABLE HYDROPHILIC ULTRAVIOLET LIGHT ABSORBING MONOMERS Pharmacia & Upjohn Groningen BV (NL) 2001-02-28 EP claimed
EP-0889916-A4 HIGH REFRACTIVE INDEX HYDROGELS PREPARED FROM POLYMERS AND COPOLYMERS OF N-BENZYL-N-METHYLACRYLAMIDE PHARMACIA IOVISION INC (US) 2000-06-28 EP claimed
US-6036891-A 2-(2'-HYDROXY-5'-(METH)ACRYLOXYALKOXYALKYLPHENYL)-2H-BENZOTRIAZOLE MONOMERS WHICH FORM OPTICALLY CLEAR ULTRAVIOLET LIGHT ABSORBING HYDROGELS USEFUL IN INTRAOCULAR LENSES, CONTACT LENSES PHARMACIA & UPJOHN (US) 2000-03-14 US claimed
WO-1999058507-A1 POLYMERIZABLE HYDROPHILIC ULTRAVIOLET LIGHT ABSORBING MONOMERS PHARMACIA & UPJOHN GRONINGEN B.V. (NL) 1999-11-18 WO claimed
CN-1219179-A High refractive index hydrogels prepared from polymers and copolymers of N-benzyl-N-methylacrylamide PHARMACIA IOVISION INC (US) 1999-06-09 CN claimed
EP-0889916-A1 HIGH REFRACTIVE INDEX HYDROGELS PREPARED FROM POLYMERS AND COPOLYMERS OF N-BENZYL-N-METHYLACRYLAMIDE Pharmacia Iovision Inc. (US) 1999-01-13 EP claimed
US-5717049-A INTRAOCULAR LENSES PHARMACIA IOVISION, INC. (US) 1998-02-10 US claimed
WO-1997035896-A1 HIGH REFRACTIVE INDEX HYDROGELS PREPARED FROM POLYMERS AND COPOLYMERS OF N-BENZYL-N-METHYLACRYLAMIDE PHARMACIA IOVISION INC. (US) 1997-10-02 WO claimed
WO-1996000248-A1 WATER MISCIBLE NON-HYDROLYZABLE CROSS-LINKERS AND HIGH REFRACTIVE INDEX HYDROGELS PREPARED THEREWITH KABI PHARMACIA OPHTHALMICS, INC. (US) 1996-01-04 WO claimed
US-5439950-A Intraocular lenses KABI PHARMACIA OPHTHALMICS, INC. (US) 1995-08-08 US claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20130287700-A1 COMPOUNDS FOR THE DIAGNOSIS OF NEURODEGENERATIVE DISORDERS ON THE OLFACTORY EPITHELIUM SNCA, MAPT, TARDBP HDAC8 4540/4885ALDH1A1 1165/4885MAPT 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.