Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 2/20 | 0.41 |
| ▸ | CCR1 | P32246 | 1/20 | 0.32 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1825784 | 0.86 | KCNJ1 (0.48) | KCNJ1CCR1 | |
| SCHEMBL872286 | 0.86 | HDAC8 (0.37) | HDAC8 | |
| Iodide SCHEMBL28714110 | 0.83 | KCNJ1 (0.47) | KCNJ1CCR1 | |
| SCHEMBL934260 | 0.72 | — | — | |
| SCHEMBL9316936 | 0.72 | — | — | |
| SCHEMBL5040448 | 0.72 | — | — | |
| SCHEMBL1913986 | 0.72 | — | — | |
| SCHEMBL14941176 | 0.72 | — | — | |
| SCHEMBL1107417 | 0.72 | — | — | |
| SCHEMBL29642530 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-113912617-A | Substituted tricycles and methods of use | 艾伯维公司 | 2022-01-11 | — | — | CN | disclosed |
| CN-108349930-B | Substituted tricycles and methods of use | 艾伯维公司 | 2021-10-29 | — | — | CN | disclosed |
| US-20190135827-A1 | Substituted Tricyclics and Method of Use | ABBVIE SARL (LU) | 2019-05-09 | — | — | US | disclosed |
| CN-108349930-A | Substituted Tricycles and Methods of Use | 艾伯维公司 | 2018-07-31 | — | — | CN | disclosed |
| EP-3322697-A1 | SUBSTITUTED TRICYCLICS AND METHOD OF USE | Abbvie S.a.r.l. (LU) | 2018-05-23 | — | — | EP | disclosed |
| US-9978474-B2 | Conductive open frameworks | THE REGENTS OF THE UNIVERSITY OF CALIFORNIA (US) | 2018-05-22 | — | — | US | disclosed |
| US-20180037587-A1 | Substituted Tricyclics and Method of Use | ABBVIE S.Á.R.L. (LU) | 2018-02-08 | — | — | US | disclosed |
| US-9840513-B2 | Substituted tricyclics and method of use | ABBVIE S.Á.R.L. (LU) | 2017-12-12 | — | — | US | disclosed |
| US-20170015675-A1 | SUBSTITUTED TRICYCLICS AND METHOD OF USE | ABBVIE OVERSEAS S.Á.R.L. (LU) | 2017-01-19 | — | — | US | disclosed |
| WO-2017009804-A1 | SUBSTITUTED TRICYCLICS AND METHOD OF USE | ABBVIE S.Á.R.L. (LU) | 2017-01-19 | — | — | WO | disclosed |
| US-20160247593-A1 | CONDUCTIVE OPEN FRAMEWORKS | UNITED STATES DEPARTMENT OF ENERGY | 2016-08-25 | — | — | US | disclosed |
| US-4981978-A | Reaction products of imidazole on pyrazole derivatives and 4-isopropenyl-1-cyclohexene-1-carboxaldehyde | THE DOW CHEMICAL COMPANY (US) | 1991-01-01 | — | — | US | disclosed |
| US-4927932-A | Reaction products of pyrimidine, pyridazine and 4-isopropenyl-1-cyclohexene-1-carboxaldehyde | THE DOW CHEMICAL COMPANY (US) | 1990-05-22 | — | — | US | disclosed |
| US-4831137-A | Reaction products of pteridine and 4-isopropenyl-1-cyclohexene-1-carboxaldehyde | THE DOW CHEMICAL COMPANY (US) | 1989-05-16 | — | — | US | disclosed |
| US-4755600-A | Reaction products of pyrazine, pyridine, quinoline and quinoxaline derivatives and 4-isopropenyl-1-cyclohexene-1-carboxaldehyde | THE DOW CHEMICAL COMPANY (US) | 1988-07-05 | — | — | US | disclosed |
| US-4680347-A | Thermosettable polystyrylpyrazine polymers terminated with ethylenically unsaturated groups and cured products therefrom | THE DOW CHEMICAL COMPANY (US) | 1987-07-14 | — | — | US | disclosed |
| EP-0220204-A1 | THERMOSETTABLE POLYSTYRYLPYRIDINE PREPOLYMER TERMINATED WITH ETHYLENICALLY UNSATURATED GROUPS AND CURED PRODUCTS THEREFROM | THE DOW CHEMICAL COMPANY (US) | 1987-05-06 | — | — | EP | disclosed |
| US-4629770-A | Thermosettable polystyrylpyrazine polymers terminated with ethylenically unsaturated groups and cured products therefrom | THE DOW CHEMICAL COMPANY (US) | 1986-12-16 | — | — | US | disclosed |
| WO-1986006386-A1 | THERMOSETTABLE POLYSTYRYLPYRIDINE PREPOLYMER TERMINATED WITH ETHYLENICALLY UNSATURATED GROUPS AND CURED PRODUCTS THEREFROM | THE DOW CHEMICAL COMPANY (US) | 1986-11-06 | — | — | WO | disclosed |
| US-4575542-A | Thermosettable polystyrylpyridine prepolymer terminated with ethylenically unsaturated groups and cured products therefrom | THE DOW CHEMICAL COMPANY (US) | 1986-03-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160247593-A1 | CONDUCTIVE OPEN FRAMEWORKS | GJB2, OR10J3, EPCAM | KCNJ1 136/4885CCR1 1573/4885HDAC8 4480/4885 |
| US-20170015675-A1 | SUBSTITUTED TRICYCLICS AND METHOD OF USE | CFTR, F12, CHRM2 | KCNJ1 724/4885CCR1 32/4885HDAC8 2763/4885 |
| US-20190135827-A1 | Substituted Tricyclics and Method of Use | CFTR, F12, CHRM2 | KCNJ1 724/4885CCR1 32/4885HDAC8 2763/4885 |
| US-20180037587-A1 | Substituted Tricyclics and Method of Use | CFTR, F12, CHRM2 | KCNJ1 724/4885CCR1 32/4885HDAC8 2763/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.