Known targets — ChEMBL curated mechanism
ACEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ATP4AATP4BAXLBTKCACNA1CCACNA1DCACNA1FCACNA1SCCR5CHRM2CHRM3CPT1BCPT2DPP4DRD1DRD2EGFRERBB2ERBB4FLT3HRH1HRH3HTR1AHTR2AHTR2BHTR2CHTR4JAK1JAK2JAK3KCNH2KMT2AMAP2K1MAP2K2MEN1MLNRMPLMTORPPIK3CAPIK3CBPIK3CDPIK3CGPIK3R1PIK3R2PIK3R3PIK3R5PLK4PPARGRENS1PR1SLC6A2SLC6A3SLC6A4SMOTYK2atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL8723374 | 1.00 | — | — | |
| Fumaric Acid SCHEMBL8722974 | 0.95 | — | — | |
| Fumaric Acid SCHEMBL14717096 | 0.76 | CA1 (0.41) | — | |
| Fumaric Acid SCHEMBL8722977 | 0.73 | TSHR (0.45) | — | |
| Fumaric Acid SCHEMBL122164 | 0.72 | — | — | |
| Fumaric Acid SCHEMBL122162 | 0.72 | — | — | |
| Fumaric Acid SCHEMBL27484728 | 0.72 | CA1 (0.43) | — | |
| Fumaric Acid SCHEMBL30895862 | 0.72 | CA1 (0.43) | — | |
| Fumaric Acid SCHEMBL372273 | 0.72 | — | — | |
| SCHEMBL253509 | 0.72 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0818194-A2 | Lubricant compositions that are spreadable onto and adherable to biomembranes, method of making and use thereof | McNEIL-PPC, INC. (US) | 1998-01-14 | — | — | EP | claimed |