Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APOBEC3A | P31941 | 1/20 | 0.52 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | RAD52 | P43351 | 1/20 | 0.49 |
| ▸ | BRAF | P15056 | 3/20 | 0.48 |
| ▸ | MEN1 | O00255 | 4/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 4/20 | 0.46 |
| ▸ | RIPK2 | O43353 | 3/20 | 0.46 |
| ▸ | COQ8A | Q8NI60 | 3/20 | 0.46 |
| ▸ | NLK | Q9UBE8 | 3/20 | 0.46 |
| ▸ | IGF1R | P08069 | 3/20 | 0.44 |
| ▸ | FLT1 | P17948 | 1/20 | 0.44 |
| ▸ | FLT4 | P35916 | 1/20 | 0.44 |
| ▸ | KDR | P35968 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | SRC | P12931 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8727112 | 0.84 | ABCG2 (0.46) | MEN1KMT2AMAPTSMN1; SMN2FLT1 | |
| SCHEMBL8723586 | 0.76 | BRAF (0.49) | APOBEC3AAPOBEC3GPOLBRAD52BRAF | |
| SCHEMBL5841124 | 0.75 | BRAF (0.69) | APOBEC3AAPOBEC3GPOLBRAD52BRAF | |
| SCHEMBL6440705 | 0.75 | RAB9A (0.55) | POLBRAD52MEN1KMT2AMAPT | |
| SCHEMBL4932459 | 0.75 | MAPT (0.51) | POLBMEN1KMT2AMAPTMAPK1 | |
| SCHEMBL6986651 | 0.74 | MEN1 (0.53) | POLBMEN1KMT2AMAPTMAPK1 | |
| SCHEMBL27982530 | 0.72 | KMT2A (0.53) | MEN1KMT2AMAPTMAPK1EGFR | |
| SCHEMBL27995633 | 0.71 | KDM4E (0.45) | APOBEC3AAPOBEC3GMEN1KMT2AMAPT | |
| SCHEMBL6193076 | 0.71 | BRAF (0.48) | APOBEC3AAPOBEC3GPOLBRAD52BRAF | |
| SCHEMBL15389323 | 0.71 | CCNK (0.43) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832091-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040705-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |