Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 5/20 | 0.49 |
| ▸ | MEN1 | O00255 | 4/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.49 |
| ▸ | EGFR | P00533 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAD52 | P43351 | 1/20 | 0.46 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.46 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.44 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.44 |
| ▸ | GAK | O14976 | 5/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 4/20 | 0.44 |
| ▸ | COQ8A | Q8NI60 | 4/20 | 0.44 |
| ▸ | NLK | Q9UBE8 | 4/20 | 0.44 |
| ▸ | SRC | P12931 | 2/20 | 0.44 |
| ▸ | LCK | P06239 | 2/20 | 0.44 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.44 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.44 |
| ▸ | ABL1 | P00519 | 1/20 | 0.44 |
| ▸ | EPHA1 | P21709 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8727116 | 0.81 | EGFR (0.45) | MEN1KMT2AEGFRLMNASRC | |
| SCHEMBL5841124 | 0.81 | BRAF (0.69) | BRAFMEN1KMT2AEGFRPOLB | |
| SCHEMBL6193076 | 0.80 | BRAF (0.48) | BRAFMEN1KMT2AEGFRPOLB | |
| SCHEMBL17948239 | 0.79 | MEN1 (0.71) | BRAFMEN1KMT2AEGFRPOLB | |
| SCHEMBL3631829 | 0.78 | BRAF (0.70) | BRAFMEN1KMT2AEGFRPOLB | |
| SCHEMBL8723583 | 0.76 | APOBEC3A (0.52) | BRAFMEN1KMT2AEGFRPOLB | |
| SCHEMBL3537888 | 0.75 | CA9 (0.51) | MEN1KMT2AAPOBEC3GGAKMAPT | |
| SCHEMBL5547719 | 0.73 | L3MBTL1 (0.41) | MEN1KMT2APOLBRAD52SRC | |
| SCHEMBL6154131 | 0.72 | MAPT (0.74) | MEN1KMT2APOLBRAD52LMNA | |
| SCHEMBL12467721 | 0.72 | HSD17B10 (0.44) | MEN1KMT2ARAD52ALOX12MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832091-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040705-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |