Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCG2 | Q9UNQ0 | 5/20 | 0.46 |
| ▸ | EGFR | P00533 | 3/20 | 0.44 |
| ▸ | CLK1 | P49759 | 1/20 | 0.44 |
| ▸ | STK10 | O94804 | 1/20 | 0.44 |
| ▸ | SLK | Q9H2G2 | 1/20 | 0.44 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | ABCB1 | P08183 | 2/20 | 0.43 |
| ▸ | ABCC1 | P33527 | 2/20 | 0.43 |
| ▸ | FLT1 | P17948 | 1/20 | 0.43 |
| ▸ | FLT4 | P35916 | 1/20 | 0.43 |
| ▸ | KDR | P35968 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8723583 | 0.84 | APOBEC3A (0.52) | EGFRLCKFLT1FLT4KDR | |
| SCHEMBL6440705 | 0.78 | RAB9A (0.55) | SMN1; SMN2NPC1RAB9AALDH1A1HTT | |
| SCHEMBL6986651 | 0.77 | MEN1 (0.53) | ABCG2EGFRCLK1ABCB1ABCC1 | |
| SCHEMBL8727116 | 0.76 | EGFR (0.45) | ABCG2EGFRCLK1LCKSMN1; SMN2 | |
| SCHEMBL8597483 | 0.75 | MEN1 (0.62) | ABCG2STK10SLKABCB1ABCC1 | |
| SCHEMBL27982530 | 0.75 | KMT2A (0.53) | EGFRNPC1ALDH1A1HTTMAPT | |
| SCHEMBL4932459 | 0.75 | MAPT (0.51) | EGFRSMN1; SMN2NPC1RAB9AALDH1A1 | |
| SCHEMBL15389323 | 0.74 | CCNK (0.43) | EGFR | |
| SCHEMBL8725290 | 0.74 | POLB (0.41) | EGFRALDH1A1HTTMAPTKDM4E | |
| SCHEMBL6418064 | 0.72 | HPGD (0.54) | SMN1; SMN2NPC1RAB9AALDH1A1HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832091-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040705-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |