Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Ammonia Solution, Strong. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ammonia Solution, Strong SCHEMBL10479108 | 0.87 | — | — | |
| Ammonia Solution, Strong SCHEMBL5422753 | 0.87 | — | — | |
| Ammonia Solution, Strong SCHEMBL5144360 | 0.87 | — | — | |
| Ammonia Solution, Strong SCHEMBL219475 | 0.87 | — | — | |
| Ammonia Solution, Strong SCHEMBL162701 | 0.87 | — | — | |
| Ammonia Solution, Strong SCHEMBL5583382 | 0.75 | — | — | |
| Ammonia Solution, Strong SCHEMBL583142 | 0.75 | — | — | |
| Ammonia Solution, Strong SCHEMBL4976170 | 0.75 | — | — | |
| Hydrochloric Acid SCHEMBL2965876 | 0.71 | — | — | |
| Hydrochloric Acid SCHEMBL11150424 | 0.71 | CYP3A4 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5759389-A | Dechlorination of TCE with palladized iron | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1998-06-02 | — | — | US | disclosed |
| EP-0799159-A1 | DECHLORINATION OF TCE WITH PALLADIZED IRON | Research Corporation Technologies, Inc (US) | 1997-10-08 | — | — | EP | disclosed |
| US-5616253-A | Dechlorination of TCE with palladized iron | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1997-04-01 | — | — | US | disclosed |
| US-5611936-A | Dechlorination of TCE with palladized iron | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1997-03-18 | — | — | US | disclosed |
| WO-1996020137-A1 | DECHLORINATION OF TCE WITH PALLADIZED IRON | RESEARCH CORPORATION TECHNOLOGIES, INC. (US) | 1996-07-04 | — | — | WO | disclosed |