Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | HTR1D | P28221 | 1/20 | 0.42 |
| ▸ | HTR1B | P28222 | 1/20 | 0.42 |
| ▸ | HTR1F | P30939 | 1/20 | 0.42 |
| ▸ | TMIGD3 | P0DMS9 | 1/20 | 0.38 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.35 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.34 |
| ▸ | TRPV6 | Q9H1D0 | 1/20 | 0.34 |
| ▸ | L3MBTL3 | Q96JM7 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.33 |
| ▸ | KCNK9 | Q9NPC2 | 1/20 | 0.33 |
| ▸ | CDK1 | P06493 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | KDM4A | O75164 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8586460 | 0.80 | HTR1F (0.45) | HTR1AHTR1DHTR1BHTR1FTMIGD3 | |
| SCHEMBL30909149 | 0.77 | HTR1F (0.75) | HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL8386474 | 0.73 | HTR1D (0.51) | HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL8721836 | 0.73 | TMIGD3 (0.41) | HTR1AHTR1DHTR1BHTR1FTMIGD3 | |
| SCHEMBL8383872 | 0.71 | HTR1F (0.72) | HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL8386639 | 0.70 | HTR1D (0.52) | HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL5309428 | 0.69 | LRRK2 (0.42) | HTR1AHTR1DHTR1BHTR1FRAB9A | |
| SCHEMBL8381834 | 0.69 | RAB9A (0.40) | HTR1AHTR1DHTR1BHTR1FTMIGD3 | |
| SCHEMBL8387305 | 0.68 | HTR1F (0.73) | HTR1AHTR1DHTR1BHTR1F | |
| SCHEMBL8586359 | 0.67 | HTR1F (0.53) | HTR1AHTR1DHTR1BHTR1FRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0875513-A1 | Substituted heteroaromatic 5-HT 1F agonists | ELI LILLY AND COMPANY (US) | 1998-11-04 | — | — | EP | disclosed |