Known targets — ChEMBL curated mechanism
FGFR1FGFR2FGFR3FGFR4FLT1FLT4KDRPDGFRAPDGFRB
The experimentally established mechanism targets of Acetic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.53 |
| ▸ | CA4 | P22748 | 4/20 | 0.40 |
| ▸ | FFAR3 | O14843 | 2/20 | 0.39 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.39 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CES1 | P23141 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.35 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.32 |
| ▸ | CASP1 | P29466 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | FAHD1 | Q6P587 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acetic Acid SCHEMBL8458828 | 0.97 | CA1 (0.56) | CA1CA4FFAR3HDAC3HDAC1 | |
| SCHEMBL28120141 | 0.82 | CA1 (0.37) | CA1CA4FFAR3HDAC3HDAC1 | |
| Acetic Acid SCHEMBL8723843 | 0.82 | FFAR3 (0.41) | CA1FFAR3HDAC3HDAC1HDAC2 | |
| Sulfuric Acid SCHEMBL29052971 | 0.81 | CA1 (0.60) | CA1CA4FFAR3HDAC3HDAC1 | |
| Methacrylic Acid SCHEMBL154990 | 0.81 | CA4 (0.41) | CA1CA4FFAR3HDAC3HDAC1 | |
| Sulfuric Acid SCHEMBL7111861 | 0.81 | CA1 (0.69) | CA1CA4FFAR3HDAC3HDAC1 | |
| Water SCHEMBL16965845 | 0.80 | CA5A (0.42) | CA1CA4FFAR3ALDH1A1TSHR | |
| Water SCHEMBL475121 | 0.80 | — | — | |
| Water SCHEMBL27458253 | 0.80 | — | — | |
| Methacrylic Acid SCHEMBL27130007 | 0.78 | CA4 (0.38) | CA1CA4FFAR3HDAC3HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5776974-A | Immunosuppressant compounds | THE UNIVERSITY OF NOTTINGHAM (GB) | 1998-07-07 | — | — | US | disclosed |