Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.64 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.45 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.45 |
| ▸ | MEN1 | O00255 | 3/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.45 |
| ▸ | THPO | P40225 | 2/20 | 0.45 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.45 |
| ▸ | ACHE | P22303 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8726309 | 0.90 | KMT2A (0.61) | KMT2ALMNAALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL7900436 | 0.89 | KMT2A (0.69) | KMT2ALMNAALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL8723896 | 0.89 | KMT2A (0.69) | KMT2ALMNAALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL8727524 | 0.86 | KMT2A (0.67) | KMT2ALMNAALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL7906473 | 0.81 | KMT2A (0.52) | KMT2ALMNAALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL14497664 | 0.79 | NPSR1 (0.59) | KMT2ALMNAMEN1TDP1NPSR1 | |
| Alalon SCHEMBL31687764 | 0.78 | KMT2A (0.65) | KMT2ALMNAALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL7465257 | 0.78 | CYP4F2 (0.51) | KMT2ALMNAALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL7719488 | 0.77 | KMT2A (0.49) | KMT2ALMNAALDH1A1CYP3A4SMN1; SMN2 | |
| SCHEMBL7466474 | 0.75 | LMNA (0.60) | KMT2ALMNAALDH1A1CYP3A4SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0651740-B1 | AMINO ACID LINKED NITROGEN MUSTARD DERIVATIVES AND THEIR USE AS PRODRUGS IN THE TREATMENT OF TUMOURS | ZENECA LTD (GB) | 1998-10-21 | — | — | EP | claimed |
| EP-0651740-B1 | AMINO ACID LINKED NITROGEN MUSTARD DERIVATIVES AND THEIR USE AS PRODRUGS IN THE TREATMENT OF TUMOURS | ZENECA LTD (GB) | 1998-10-21 | — | — | EP | disclosed |