Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.69 |
| ▸ | LMNA | P02545 | 3/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.53 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.53 |
| ▸ | THPO | P40225 | 2/20 | 0.53 |
| ▸ | PMP22 | Q01453 | 2/20 | 0.53 |
| ▸ | GMNN | O75496 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.53 |
| ▸ | TSHR | P16473 | 1/20 | 0.53 |
| ▸ | GABRA2 | P47869 | 1/20 | 0.53 |
| ▸ | GABRB2 | P47870 | 1/20 | 0.53 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.53 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.49 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.49 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7900436 | 1.00 | KMT2A (0.69) | KMT2ALMNAALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL8727524 | 0.91 | KMT2A (0.67) | KMT2ALMNAALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL8723902 | 0.89 | KMT2A (0.64) | KMT2ALMNAALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL14497664 | 0.88 | NPSR1 (0.59) | KMT2ALMNATDP1MEN1FOLH1 | |
| SCHEMBL8726309 | 0.86 | KMT2A (0.61) | KMT2ALMNAALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL8722784 | 0.83 | KMT2A (0.49) | KMT2ALMNAALDH1A1MEN1FOLH1 | |
| SCHEMBL7719488 | 0.83 | KMT2A (0.49) | KMT2ALMNAALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL9014687 | 0.82 | CA2 (0.56) | KMT2ALMNAALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL1064767 | 0.82 | CA2 (0.56) | KMT2ALMNAALDH1A1SMN1; SMN2HIF1A | |
| SCHEMBL4469539 | 0.82 | LMNA (0.49) | KMT2ALMNAALDH1A1SMN1; SMN2HIF1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0651740-B1 | AMINO ACID LINKED NITROGEN MUSTARD DERIVATIVES AND THEIR USE AS PRODRUGS IN THE TREATMENT OF TUMOURS | ZENECA LTD (GB) | 1998-10-21 | — | — | EP | claimed |
| EP-0651740-B1 | AMINO ACID LINKED NITROGEN MUSTARD DERIVATIVES AND THEIR USE AS PRODRUGS IN THE TREATMENT OF TUMOURS | ZENECA LTD (GB) | 1998-10-21 | — | — | EP | disclosed |