Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
| ▸ | CNR2 | P34972 | 1/20 | 0.45 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.43 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | LPL | P06858 | 2/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.38 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.37 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.37 |
| ▸ | BACE1 | P56817 | 1/20 | 0.36 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.34 |
| ▸ | MGLL | Q99685 | 1/20 | 0.33 |
| ▸ | PLK1 | P53350 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9740304 | 0.79 | CNR1 (0.50) | CNR1CNR2ALOX5CA2LPL | |
| SCHEMBL1263571 | 0.76 | CNR1 (0.47) | CNR1CNR2ALOX5CA2LPL | |
| SCHEMBL5048783 | 0.76 | CNR1 (0.47) | CNR1CNR2ALOX5CA2LPL | |
| SCHEMBL8729657 | 0.75 | CNR1 (0.35) | CNR1CNR2ALOX5LPLLIPG | |
| SCHEMBL7294423 | 0.74 | CNR1 (0.45) | CNR1CNR2ALOX5CA2LPL | |
| SCHEMBL7637395 | 0.74 | CNR1 (0.45) | CNR1CNR2ALOX5LPLLIPG | |
| SCHEMBL9100129 | 0.74 | CNR1 (0.45) | CNR1CNR2ALOX5CA2LPL | |
| SCHEMBL1021086 | 0.74 | ALOX5 (0.71) | CNR1CNR2ALOX5GABRA1GABRB2 | |
| SCHEMBL18536578 | 0.74 | CNR1 (0.41) | CNR1CNR2ALOX5CA2LPL | |
| SCHEMBL10923709 | 0.73 | TRPA1 (0.43) | CA2BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609058-B1 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-12-09 | — | — | EP | disclosed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0609058-A2 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-08-03 | — | — | EP | disclosed |