Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CNR2 | P34972 | 1/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | HMGCR | P04035 | 1/20 | 0.33 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.33 |
| ▸ | PTPN11 | Q06124 | 2/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.32 |
| ▸ | LPL | P06858 | 2/20 | 0.32 |
| ▸ | LIPG | Q9Y5X9 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.31 |
| ▸ | GABRA5 | P31644 | 1/20 | 0.31 |
| ▸ | GABRA3 | P34903 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11355625 | 0.77 | HTT (0.37) | CNR1CNR2ALOX5CYP3A4ALDH1A1 | |
| SCHEMBL11684526 | 0.77 | HPGD (0.37) | CNR1CNR2ALOX5CYP3A4ALDH1A1 | |
| SCHEMBL6131303 | 0.75 | GABRA1 (0.37) | CNR1CNR2ALOX5CYP3A4ALDH1A1 | |
| SCHEMBL16575401 | 0.75 | HMGCR (0.38) | CNR1CNR2ALOX5CYP3A4ALDH1A1 | |
| SCHEMBL18378625 | 0.75 | CNR1 (0.35) | CNR1CNR2ALOX5CYP3A4ALDH1A1 | |
| SCHEMBL7299326 | 0.75 | PTPN1 (0.36) | CNR1CNR2ALOX5CYP3A4ALDH1A1 | |
| SCHEMBL16575403 | 0.75 | CNR1 (0.35) | CNR1CNR2ALOX5CYP3A4ALDH1A1 | |
| SCHEMBL1023215 | 0.75 | DHFR (0.45) | CNR1CNR2ALOX5CYP3A4HMGCR | |
| SCHEMBL8724867 | 0.75 | CNR1 (0.45) | CNR1CNR2ALOX5LPLLIPG | |
| SCHEMBL7700304 | 0.74 | CNR1 (0.46) | CNR1CNR2CYP3A4ALDH1A1PTGS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609058-B1 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-12-09 | — | — | EP | disclosed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0609058-A2 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-08-03 | — | — | EP | disclosed |