Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.44 |
| ▸ | HPGD | P15428 | 3/20 | 0.44 |
| ▸ | CA1 | P00915 | 2/20 | 0.44 |
| ▸ | CA2 | P00918 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.44 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | FYN | P06241 | 1/20 | 0.44 |
| ▸ | MMP2 | P08253 | 1/20 | 0.44 |
| ▸ | MMP9 | P14780 | 1/20 | 0.44 |
| ▸ | MMP8 | P22894 | 1/20 | 0.44 |
| ▸ | CA6 | P23280 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | MMP12 | P39900 | 1/20 | 0.44 |
| ▸ | RECQL | P46063 | 1/20 | 0.44 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.44 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.44 |
| ▸ | DBH | P09172 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054160 | 0.83 | LMNA (0.44) | LMNAHPGDCA1CA2ALDH1A1 | |
| SCHEMBL9750794 | 0.83 | TSHR (0.48) | LMNAHPGDCA2ALDH1A1ALOX15 | |
| SCHEMBL11043623 | 0.81 | ADRA2A (0.55) | LMNAHPGDCA1CA2ALDH1A1 | |
| SCHEMBL4334723 | 0.81 | ADRA2A (0.55) | LMNAHPGDCA1CA2ALDH1A1 | |
| SCHEMBL632462 | 0.78 | TSHR (0.48) | LMNAHPGDCA1CA2ALDH1A1 | |
| SCHEMBL16638968 | 0.76 | LMNA (0.50) | LMNAHPGDCA1CA2ALDH1A1 | |
| SCHEMBL135746 | 0.74 | LMNA (0.50) | LMNAHPGDCA1CA2ALDH1A1 | |
| SCHEMBL10867172 | 0.71 | TSHR (0.38) | LMNAHPGDALOX15RECQLTDP1 | |
| SCHEMBL8582907 | 0.70 | LMNA (0.55) | LMNAHPGDCA1CA2ALDH1A1 | |
| SCHEMBL9495858 | 0.70 | HPGD (0.48) | LMNAHPGDCA1CA2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5227333-A | Selective etchingof a semiconductor substrate covered by a blanket of germanium and an overcoating of an electroconductive layer | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 1993-07-13 | — | — | US | claimed |
| US-4065840-A | Method for fabricating a DSDT target | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 1978-01-03 | — | — | US | claimed |
| JP-55022836-A | — | — | None | — | — | JP | disclosed |
| EP-3394057-B1 | SYNTHETIC METHOD FOR PREPARATION OF (S)-(2R,3R,11BR)-3-ISOBUTYL-9,10-DIMETHOXY-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRIDO[2,1,-A]LSOQUINOLIN-2-YL 2-AMINO-3-METHYLBUTANOATE DI(4-METHYLBENZENESULFONATE) | NEUROCRINE BIOSCIENCES INC (US) | 2022-03-30 | — | — | EP | disclosed |
| US-10919892-B2 | Synthetic methods for preparation of (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate) | NEUROCRINE BIOSCIENCES, INC. (US) | 2021-02-16 | — | — | US | disclosed |
| US-10906902-B2 | Synthetic methods for preparation of (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1,-a]isoquinolin-2-2-amino-3-methylbutanoate di(4-methylbenzenesulfonate) | NEUROCRINE BIOSCIENCES, INC. (US) | 2021-02-02 | — | — | US | disclosed |
| US-10906903-B2 | Synthetic methods for preparation of (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1,-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate) | NEUROCRINE BIOSCIENCES, INC. (US) | 2021-02-02 | — | — | US | disclosed |
| US-20200347054-A1 | SYNTHETIC METHODS FOR PREPARATION OF (S)-(2R,3R,11BR)-3-ISOBUTYL-9,10-DIMETHOXY-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRIDO[2,1,-A]lSOQUINOLIN-2-YL 2-AMINO-3-METHYLBUTANOATE DI(4-METHYLBENZENESULFONATE) | NEUROCRINE BIOSCIENCES, INC. | 2020-11-05 | — | — | US | disclosed |
| US-20200347056-A1 | SYNTHETIC METHODS FOR PREPARATION OF (S)-(2R,3R,11BR)-3-ISOBUTYL-9,10-DIMETHOXY-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRIDO[2,1,-A]lSOQUINOLIN-2-YL 2-AMINO-3-METHYLBUTANOATE DI(4-METHYLBENZENESULFONATE) | NEUROCRINE BIOSCIENCES, INC. | 2020-11-05 | — | — | US | disclosed |
| US-20200347057-A1 | SYNTHETIC METHODS FOR PREPARATION OF (S)-(2R,3R,11BR)-3-ISOBUTYL-9,10-DIMETHOXY-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRIDO[2,1,-A]lSOQUINOLIN-2-YL 2-AMINO-3-METHYLBUTANOATE DI(4-METHYLBENZENESULFONATE) | AGNO PHARMA USA | 2020-11-05 | — | — | US | disclosed |
| US-20200347055-A1 | SYNTHETIC METHODS FOR PREPARATION OF (S)-(2R,3R,11BR)-3-ISOBUTYL-9,10-DIMETHOXY-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRIDO[2,1,-A]lSOQUINOLIN-2-YL 2-AMINO-3-METHYLBUTANOATE DI(4-METHYLBENZENESULFONATE) | NEUROCRINE BIOSCIENCES, INC. | 2020-11-05 | — | — | US | disclosed |
| US-5751156-A | Mechanically controllable break transducer | YALE UNIVERSITY (US) | 1998-05-12 | — | — | US | disclosed |
| EP-0144762-B1 | METHODS FOR FORMING CLOSELY SPACED OPENINGS AND FOR MAKING CONTACTS TO SEMICONDUCTOR DEVICE SURFACES | International Business Machines Corporation (US) | 1988-10-19 | — | — | EP | disclosed |
| US-4641170-A | Self-aligned lateral bipolar transistors | INTERNATIONAL BUSINESS MACHINES CORPORATION | 1987-02-03 | — | — | US | disclosed |
| US-4551906-A | Method for making self-aligned lateral bipolar transistors | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 1985-11-12 | — | — | US | disclosed |
| EP-0144762-A1 | Methods for forming closely spaced openings and for making contacts to semiconductor device surfaces | International Business Machines Corporation (US) | 1985-06-19 | — | — | EP | disclosed |
| US-4407058-A | Method of making dense vertical FET's | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 1983-10-04 | — | — | US | disclosed |
| JP-S5522836-A | SEMICONDUCTOR DEVICE | KANDA YOZO | 1980-02-18 | — | — | JP | disclosed |
| US-4065840-A | Method for fabricating a DSDT target | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 1978-01-03 | — | — | US | disclosed |
| US-3971860-A | Method for making device for high resolution electron beam fabrication | INTERNATIONAL BUSINESS MACHINES CORPORATION (US) | 1976-07-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (7 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20200347054-A1 | SYNTHETIC METHODS FOR PREPARATION OF (S)-(2R,3R,11BR)-3-ISOBUTYL-9,10-DIMETHOXY-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRIDO[2,1,-A]lSOQUINOLIN-2-YL 2-AMINO-3-METHYLBUTANOATE DI(4-METHYLBENZENESULFONATE) | CYP2S1, CYP26B1, UGT2B7 | LMNA 387/4885HPGD 1475/4885CA1 3558/4885 |
| US-20200347055-A1 | SYNTHETIC METHODS FOR PREPARATION OF (S)-(2R,3R,11BR)-3-ISOBUTYL-9,10-DIMETHOXY-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRIDO[2,1,-A]lSOQUINOLIN-2-YL 2-AMINO-3-METHYLBUTANOATE DI(4-METHYLBENZENESULFONATE) | CYP2S1, CYP26B1, UGT2B7 | LMNA 387/4885HPGD 1475/4885CA1 3558/4885 |
| US-20200347056-A1 | SYNTHETIC METHODS FOR PREPARATION OF (S)-(2R,3R,11BR)-3-ISOBUTYL-9,10-DIMETHOXY-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRIDO[2,1,-A]lSOQUINOLIN-2-YL 2-AMINO-3-METHYLBUTANOATE DI(4-METHYLBENZENESULFONATE) | CYP2S1, CYP26B1, UGT2B7 | LMNA 387/4885HPGD 1475/4885CA1 3558/4885 |
| US-20200347057-A1 | SYNTHETIC METHODS FOR PREPARATION OF (S)-(2R,3R,11BR)-3-ISOBUTYL-9,10-DIMETHOXY-2,3,4,6,7,11B-HEXAHYDRO-1H-PYRIDO[2,1,-A]lSOQUINOLIN-2-YL 2-AMINO-3-METHYLBUTANOATE DI(4-METHYLBENZENESULFONATE) | CYP2S1, CYP26B1, UGT2B7 | LMNA 387/4885HPGD 1475/4885CA1 3558/4885 |
| US-10919892-B2 | Synthetic methods for preparation of (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate) | CYP2S1, CYP26B1, CYP4B1 | LMNA 1865/4885HPGD 1118/4885CA1 3911/4885 |
| US-10906903-B2 | Synthetic methods for preparation of (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1,-a]isoquinolin-2-yl 2-amino-3-methylbutanoate di(4-methylbenzenesulfonate) | CYP2S1, CYP26B1, CYP4B1 | LMNA 1653/4885HPGD 1023/4885CA1 3589/4885 |
| US-10906902-B2 | Synthetic methods for preparation of (S)-(2R,3R,11bR)-3-isobutyl-9,10-dimethoxy-2,3,4,6,7,11b-hexahydro-1H-pyrido[2,1,-a]isoquinolin-2-2-amino-3-methylbutanoate di(4-methylbenzenesulfonate) | CYP2S1, CYP26B1, CYP4B1 | LMNA 1793/4885HPGD 998/4885CA1 3852/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.