Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRIM24 | O15164 | 1/20 | 0.40 |
| ▸ | TRIM33 | Q9UPN9 | 1/20 | 0.40 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | FGF23 | Q9GZV9 | 1/20 | 0.33 |
| ▸ | NFE2L2 | Q16236 | 7/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.31 |
| ▸ | ERN1 | O75460 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19597465 | 0.78 | TLR8 (0.42) | TRIM24TRIM33TLR8KMT2AFGF23 | |
| SCHEMBL24061463 | 0.77 | TLR8 (0.51) | TLR8KMT2AALDH1A1GAANPC1 | |
| SCHEMBL24440652 | 0.76 | NOS3 (0.39) | TLR8KMT2AFGF23NPC1RAB9A | |
| SCHEMBL23570007 | 0.75 | TLR8 (0.42) | TLR8KMT2AALDH1A1KDM4EMEN1 | |
| SCHEMBL346904 | 0.74 | TRIM24 (0.59) | TRIM24TRIM33KMT2AALDH1A1NPC1 | |
| SCHEMBL5943028 | 0.73 | TRIM24 (0.39) | TRIM24TRIM33KMT2AFGF23ALDH1A1 | |
| SCHEMBL8206128 | 0.72 | TLR8 (0.51) | TLR8KMT2ANFE2L2MEN1 | |
| SCHEMBL21447775 | 0.72 | KMT2A (0.35) | KMT2AFGF23MEN1NPSR1 | |
| SCHEMBL26479489 | 0.70 | FGF23 (0.34) | TRIM24TRIM33FGF23 | |
| SCHEMBL2084748 | 0.70 | TRIM24 (0.48) | TRIM24TRIM33KMT2ANFE2L2ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |