Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.45 |
| ▸ | EDNRB | P24530 | 10/20 | 0.41 |
| ▸ | EDNRA | P25101 | 10/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.38 |
| ▸ | BACE2 | Q9Y5Z0 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.37 |
| ▸ | FOLH1 | Q04609 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8726257 | 1.00 | SLC7A5 (0.45) | SLC7A5EDNRBEDNRABACE1BACE2 | |
| SCHEMBL8721687 | 0.89 | BACE1 (0.45) | SLC7A5EDNRBEDNRABACE1BACE2 | |
| SCHEMBL8722642 | 0.89 | BACE1 (0.45) | SLC7A5EDNRBEDNRABACE1BACE2 | |
| SCHEMBL16907004 | 0.87 | ALDH1A1 (0.50) | EDNRBEDNRA | |
| SCHEMBL7451078 | 0.87 | ALDH1A1 (0.50) | EDNRBEDNRA | |
| SCHEMBL7451075 | 0.87 | ALDH1A1 (0.50) | EDNRBEDNRA | |
| SCHEMBL8721883 | 0.86 | ESR1 (0.47) | EDNRBEDNRAESR1ESR2 | |
| SCHEMBL8721886 | 0.86 | ESR1 (0.47) | EDNRBEDNRAESR1ESR2 | |
| SCHEMBL8724800 | 0.86 | LDHA (0.51) | POLB | |
| SCHEMBL8724804 | 0.86 | LDHA (0.51) | POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780498-A | PEPTIDE DERIVATIVES FOR CARDIOVASCULAR AND BRAIN DISORDERS | CIBA-GEIGY JAPAN LIMITED (JP) | 1998-07-14 | — | — | US | disclosed |
| EP-0728145-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | Ciba-Geigy Japan Limited (JP) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995012611-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | JAPAT LTD. (CH) | 1995-05-11 | — | — | WO | disclosed |