Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LDHA | P00338 | 1/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | TSPO | P30536 | 1/20 | 0.45 |
| ▸ | PPARG | P37231 | 2/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | TPH1 | P17752 | 2/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8724800 | 1.00 | LDHA (0.51) | LDHAKMT2AMEN1TSPOPPARG | |
| SCHEMBL8726261 | 0.86 | SLC7A5 (0.45) | POLB | |
| SCHEMBL8726257 | 0.86 | SLC7A5 (0.45) | POLB | |
| SCHEMBL8722642 | 0.85 | BACE1 (0.45) | KMT2AMEN1TSPOPOLBL3MBTL1 | |
| SCHEMBL8721687 | 0.85 | BACE1 (0.45) | KMT2AMEN1TSPOPOLBL3MBTL1 | |
| SCHEMBL8724369 | 0.85 | TSPO (0.52) | TSPOPPARGPPARA | |
| SCHEMBL8724365 | 0.85 | TSPO (0.52) | TSPOPPARGPPARA | |
| SCHEMBL7451075 | 0.84 | ALDH1A1 (0.50) | PPARGPPARA | |
| SCHEMBL16907004 | 0.84 | ALDH1A1 (0.50) | PPARGPPARA | |
| SCHEMBL7451078 | 0.84 | ALDH1A1 (0.50) | PPARGPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5780498-A | PEPTIDE DERIVATIVES FOR CARDIOVASCULAR AND BRAIN DISORDERS | CIBA-GEIGY JAPAN LIMITED (JP) | 1998-07-14 | — | — | US | disclosed |
| EP-0728145-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | Ciba-Geigy Japan Limited (JP) | 1996-08-28 | — | — | EP | disclosed |
| WO-1995012611-A1 | ENDOTHELIN RECEPTOR ANTAGONISTS | JAPAT LTD. (CH) | 1995-05-11 | — | — | WO | disclosed |