Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | L3MBTL3 | Q96JM7 | 2/20 | 0.42 |
| ▸ | RORC | P51449 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | EED | O75530 | 1/20 | 0.39 |
| ▸ | MCHR1 | Q99705 | 5/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.38 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.37 |
| ▸ | LSS | P48449 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8729536 | 0.84 | RORC (0.47) | L3MBTL3RORCL3MBTL1EEDMCHR1 | |
| SCHEMBL8726331 | 0.83 | ADRB1 (0.50) | L3MBTL3RORCL3MBTL1EEDMCHR1 | |
| SCHEMBL8723811 | 0.83 | MCHR1 (0.43) | L3MBTL3RORCL3MBTL1MCHR1USP2 | |
| SCHEMBL1409679 | 0.81 | MAPT (0.53) | L3MBTL3RORCL3MBTL1EEDMCHR1 | |
| SCHEMBL22837830 | 0.81 | HTR2A (0.43) | L3MBTL3RORCL3MBTL1EEDMCHR1 | |
| SCHEMBL5539924 | 0.81 | L3MBTL3 (0.46) | L3MBTL3RORCL3MBTL1EEDMCHR1 | |
| SCHEMBL5539933 | 0.81 | KDM4E (0.49) | L3MBTL3RORCL3MBTL1EEDMCHR1 | |
| SCHEMBL578309 | 0.81 | NPY5R (0.49) | L3MBTL3RORCL3MBTL1EEDMCHR1 | |
| SCHEMBL21447979 | 0.81 | L3MBTL3 (0.52) | L3MBTL3RORCL3MBTL1MCHR1CYP3A4 | |
| SCHEMBL8728922 | 0.81 | L3MBTL3 (0.37) | L3MBTL3L3MBTL1MCHR1USP2LSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0624584-B1 | Piperazine derivatives useful as calmodulin inhibitors | DAIICHI SEIYAKU CO (JP) | 1998-08-19 | — | — | EP | disclosed |
| US-5681954-A | HAS CALMODULIN INHIBITORY ACTIVITY; USEFUL IN TREATING DISEASES OF THE CIRCULATORY ORGANS OR IN CEREBRAL REGION | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1997-10-28 | — | — | US | disclosed |
| EP-0624584-A1 | Piperazine derivatives useful as calmodolin inhibitors | DAIICHI PHARMACEUTICAL CO., LTD. (JP) | 1994-11-17 | — | — | EP | disclosed |