Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA1A | P35348 | 3/20 | 0.58 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.55 |
| ▸ | BLM | P54132 | 1/20 | 0.55 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.51 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.51 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.51 |
| ▸ | SCN1A | P35498 | 1/20 | 0.50 |
| ▸ | SCN2A | Q99250 | 1/20 | 0.50 |
| ▸ | SCN3A | Q9NY46 | 1/20 | 0.50 |
| ▸ | DHFR | P00374 | 1/20 | 0.50 |
| ▸ | CA1 | P00915 | 2/20 | 0.47 |
| ▸ | CA2 | P00918 | 2/20 | 0.47 |
| ▸ | CA12 | O43570 | 1/20 | 0.47 |
| ▸ | CA7 | P43166 | 1/20 | 0.47 |
| ▸ | CA9 | Q16790 | 1/20 | 0.47 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7860955 | 0.86 | CA12 (0.47) | ADRA1AADRA2ACYP2D6MEN1KMT2A | |
| SCHEMBL17388712 | 0.83 | ADRA1A (0.68) | ADRA1AADRA2ACYP2D6MEN1KMT2A | |
| SCHEMBL28695645 | 0.83 | ADRA1A (0.67) | ADRA1AADRA2ACYP2D6MEN1KMT2A | |
| SCHEMBL11044403 | 0.81 | KDM4E (0.43) | ADRA1AADRA2ACYP2D6MEN1KMT2A | |
| SCHEMBL6283315 | 0.81 | ADRA2A (0.41) | ADRA1AADRA2ACYP2D6MEN1KMT2A | |
| SCHEMBL18287881 | 0.80 | ADRA1A (0.68) | ADRA1AADRA2ACYP2D6MEN1KMT2A | |
| SCHEMBL1199570 | 0.78 | TSHR (0.47) | MEN1KMT2ACA1CA2CA12 | |
| SCHEMBL22144397 | 0.78 | TSHR (0.47) | MEN1KMT2ACA1CA2CA12 | |
| SCHEMBL9027230 | 0.78 | ADRA1A (0.69) | ADRA1AADRA2ACYP2D6MEN1KMT2A | |
| SCHEMBL7817448 | 0.78 | TRIM24 (0.53) | ADRA1AADRA2ACYP2D6MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0835107-A1 | THE USE OF ALPHA-1C-SELECTIVE ADRENOCEPTOR AGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1998-04-15 | — | — | EP | disclosed |
| US-5610174-A | Use of α1A -selective adrenoceptor agonists for the treatment of urinary incontinence | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-03-11 | — | — | US | disclosed |
| WO-1996038143-A1 | THE USE OF ALPHA-1C-SELECTIVE ADRENOCEPTOR AGONISTS FOR THE TREATMENT OF URINARY INCONTINENCE | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1996-12-05 | — | — | WO | disclosed |
| WO-1990012794-A1 | ENANTIOMER-FREE 1,2-AMINOALCOHOLS ACETALICALLY PROTECTED ON THE OXYGEN, THEIR PRODUCTION AND USE | NOE CHRISTIAN R (AT) | 1990-11-01 | — | — | WO | disclosed |