Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 3/20 | 0.46 |
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | ADAMTS5 | Q9UNA0 | 2/20 | 0.44 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.44 |
| ▸ | FOLH1 | Q04609 | 3/20 | 0.41 |
| ▸ | DHFR | P00374 | 4/20 | 0.41 |
| ▸ | MMP2 | P08253 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | TYMS | P04818 | 2/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8724180 | 0.92 | CA2 (0.45) | CA2CA1CA12CA9FOLH1 | |
| SCHEMBL8722961 | 0.91 | CA2 (0.46) | CA2CA1CA12CA9FOLH1 | |
| SCHEMBL8726491 | 0.91 | CA2 (0.47) | CA2CA1CA12CA9ADAMTS5 | |
| SCHEMBL8722053 | 0.90 | CA2 (0.46) | CA2CA1CA12CA9ADAMTS5 | |
| SCHEMBL8722076 | 0.89 | CA2 (0.41) | CA2CA1CA12CA9ADAMTS5 | |
| SCHEMBL8726497 | 0.83 | CA1 (0.49) | CA2CA1CA12CA9HDAC1 | |
| SCHEMBL8722147 | 0.83 | CA2 (0.39) | CA2CA1CA12CA9FOLH1 | |
| SCHEMBL8726202 | 0.81 | CA2 (0.46) | CA2CA1CA12CA9FOLH1 | |
| SCHEMBL8724224 | 0.81 | CA2 (0.46) | CA2CA1CA12CA9FOLH1 | |
| SCHEMBL8726187 | 0.80 | ADAMTS5 (0.36) | ADAMTS5ADAMTS4DHFRMMP2MMP8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-1998035982-A1 | COMPOUNDS FOR USE IN ADEPT | ZENECA LIMITED (GB) | 1998-08-20 | — | — | WO | disclosed |