SCHEMBL8726525

SCHEMBL8726525

C=C1c2ccccc2-c2ccc(C#N)c(C#N)c21

nearest known ligand 0.38

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
USP8 P40818 1/20 0.38
USP7 Q93009 1/20 0.38
ESR2 Q92731 1/20 0.34
AR P10275 6/20 0.34
TSHR P16473 1/20 0.32
KDM4E B2RXH2 1/20 0.31
MEN1 O00255 1/20 0.31
ALDH1A1 P00352 1/20 0.31
GAA P10253 1/20 0.31
MAPT P10636 1/20 0.31
CACNA1B Q00975 1/20 0.31
APBA1 Q02410 1/20 0.31
KMT2A Q03164 1/20 0.31
PDK2 Q15119 1/20 0.31
SMN1; SMN2 Q16637 1/20 0.31
HIF1A Q16665 1/20 0.31
LMNA P02545 1/20 0.31
PGR P06401 2/20 0.30
IMPDH2 P12268 1/20 0.30
IMPDH1 P20839 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL615483 0.80 USP8 (0.53) USP8USP7KDM4EMEN1ALDH1A1
SCHEMBL28137200 0.76 AR (0.34) USP8USP7ESR2ARTSHR
SCHEMBL8099021 0.73 USP8 (0.33) USP8USP7
SCHEMBL4342916 0.73 USP8 (0.53) USP8USP7TSHRKDM4EMEN1
SCHEMBL16422435 0.73 AR (0.33) USP8USP7ESR2ARTSHR
SCHEMBL11163889 0.72 ADORA2A (0.45) KDM4EALDH1A1MAPTSMN1; SMN2HIF1A
SCHEMBL29914867 0.68 ALDH1A1 (0.47) TSHRKDM4EMEN1ALDH1A1MAPT
SCHEMBL27909136 0.68 ALDH1A1 (0.47) TSHRKDM4EMEN1ALDH1A1MAPT
SCHEMBL920234 0.68 KDM4E (0.43) TSHRKDM4EMEN1ALDH1A1GAA
SCHEMBL17954612 0.68 SQOR (0.40) ARKDM4EMEN1ALDH1A1GAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-110361942-A Electrophtography photosensor, handle box, image forming apparatus and imide compound 富士施乐株式会社 2019-10-22 CN disclosed
EP-0643845-B1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTIVE RECORDING MATERIAL WITH CROSSLINKED BINDER AGFA GEVAERT NV (BE) 1998-01-21 EP disclosed
EP-0573085-B1 Photoconductive recording material with moisture-hardened binder system AGFA GEVAERT NV (BE) 1997-10-15 EP disclosed
US-5529867-A DIALKANOLAMINE-MODIFIED EPOXY RESIN; POLYISOCYANATE CROSSLINKING AGENT AGFA-GEVAERT, N.V. (BE) 1996-06-25 US disclosed
EP-0643845-A1 ELECTROPHOTOGRAPHIC PHOTOCONDUCTIVE RECORDING MATERIAL WITH CROSSLINKED BINDER AGFA-GEVAERT N.V. (BE) 1995-03-22 EP disclosed
WO-1993024861-A1 PHOTOCONDUCTIVE RECORDING MATERIAL WITH CROSSLINKED BINDER SYSTEM AGFA-GEVAERT NAAMLOZE VENNOOTSCHAP (BE) 1993-12-09 WO disclosed
EP-0573085-A1 Photoconductive recording material with moisture-hardened binder system AGFA-GEVAERT N.V. (BE) 1993-12-08 EP disclosed