Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 1/20 | 0.61 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.61 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.61 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.61 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.61 |
| ▸ | HPGDS | O60760 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.39 |
| ▸ | SLC6A5 | Q9Y345 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8726561 | 0.82 | PTGS2 (0.78) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL2237360 | 0.82 | PTGS2 (0.77) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8732280 | 0.81 | CXCL8 (0.65) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8732216 | 0.81 | CXCL8 (0.64) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8458232 | 0.79 | PTGS1 (0.74) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL7678497 | 0.78 | PTGS2 (0.72) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8728772 | 0.78 | PTGS1 (0.51) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8729681 | 0.77 | PTGS2 (0.70) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8731019 | 0.77 | PTGS2 (0.70) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| Tolmetin SCHEMBL11325188 | 0.76 | PTGS2 (1.00) | CXCL8AKR1B1PTGS1PTGS2GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783488-A4 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO (JP) | 1998-01-07 | — | — | EP | claimed |
| EP-0783488-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | claimed |
| WO-1996010013-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-04-04 | — | — | WO | claimed |