Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | FBP1 | P09467 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.39 |
| ▸ | TDO2 | P48775 | 1/20 | 0.39 |
| ▸ | AURKA | O14965 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | WDR5 | P61964 | 1/20 | 0.37 |
| ▸ | EGFR | P00533 | 5/20 | 0.37 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | FABP4 | P15090 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8725293 | 0.80 | IDO1 (0.42) | POLBFBP1L3MBTL1ALDH1A1TSHR | |
| SCHEMBL8725862 | 0.77 | MAPT (0.49) | POLBL3MBTL1ALDH1A1KDM4ELMNA | |
| SCHEMBL8727112 | 0.74 | ABCG2 (0.46) | ALDH1A1KDM4EHTTEGFRMAPT | |
| SCHEMBL3932390 | 0.69 | NPC1 (0.41) | POLBL3MBTL1ALDH1A1TSHRKDM4E | |
| SCHEMBL1539296 | 0.69 | L3MBTL1 (0.53) | POLBL3MBTL1ALDH1A1TSHRKDM4E | |
| SCHEMBL693995 | 0.68 | RAPGEF4 (0.45) | ALDH1A1TSHRKDM4EIDO1EGFR | |
| SCHEMBL8725838 | 0.68 | EGFR (0.39) | ALDH1A1TSHRKDM4ELMNAHTT | |
| SCHEMBL17604220 | 0.68 | HPGD (0.43) | POLBL3MBTL1ALDH1A1TSHRKDM4E | |
| SCHEMBL8723583 | 0.68 | APOBEC3A (0.52) | POLBALDH1A1KDM4ELMNAEGFR | |
| SCHEMBL7655071 | 0.67 | NQO1 (0.44) | POLBL3MBTL1ALDH1A1KDM4ELMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0832091-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA, INC. (US) | 1998-04-01 | — | — | EP | disclosed |
| WO-1996040705-A1 | C-4' MODIFIED ADENOSINE KINASE INHIBITORS | GENSIA SICOR (US) | 1996-12-19 | — | — | WO | disclosed |