Cyclopropane

Cyclopropane

SCHEMBL8727309

C1CC1.CCOC=C(C=O)C(=O)c1ccc(Cl)c(SC)c1

nearest known ligand 0.32

Full drug profile on Sugi Atlas →

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 2/20 0.32
SLC6A2 P23975 2/20 0.31
SLC6A4 P31645 2/20 0.31
SLC6A3 Q01959 2/20 0.31
MAPT P10636 1/20 0.30
HPGD P15428 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8727304 0.77 TSHR (0.35) ALDH1A1MAPTHPGD
SCHEMBL8725872 0.66 TSHR (0.59) ALDH1A1MAPT
SCHEMBL31401293 0.66 TSHR (0.59) ALDH1A1MAPT
SCHEMBL10582183 0.65 GAA (0.34) MAPTHPGD
SCHEMBL2646305 0.63 TDP1 (0.40) ALDH1A1MAPT
SCHEMBL7582102 0.62 GRM1 (0.36)
SCHEMBL8729661 0.61 ATM (0.39) ALDH1A1SLC6A4SLC6A3MAPTHPGD
SCHEMBL10740290 0.60 HDAC3 (0.40) ALDH1A1MAPTHPGD
SCHEMBL11085940 0.59 SMN1; SMN2 (0.41) ALDH1A1MAPTHPGD
SCHEMBL11807796 0.59 ALDH1A1 (0.38) ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0625508-B1 Sulfur-containing derivatives of 2-cyano-1,3-diones and their use as herbicides RHONE POULENC AGRICULTURE (GB) 1998-08-19 EP disclosed