Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTR | P02766 | 1/20 | 0.47 |
| ▸ | NSD2 | O96028 | 6/20 | 0.39 |
| ▸ | AURKA | O14965 | 1/20 | 0.39 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.39 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.38 |
| ▸ | SENP3 | Q9H4L4 | 3/20 | 0.38 |
| ▸ | SENP2 | Q9HC62 | 3/20 | 0.38 |
| ▸ | SENP1 | Q9P0U3 | 3/20 | 0.38 |
| ▸ | SUMO2 | P61956 | 2/20 | 0.38 |
| ▸ | SUMO1 | P63165 | 2/20 | 0.38 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.38 |
| ▸ | NR4A2 | P43354 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL38143 | 0.87 | TTR (0.50) | TTRNSD2AURKAAURKBNR4A2 | |
| SCHEMBL28444885 | 0.85 | TTR (0.48) | TTRNSD2AURKAAURKBNR4A2 | |
| SCHEMBL28977927 | 0.84 | TTR (0.46) | TTRNSD2AURKAAURKBSENP3 | |
| SCHEMBL28977925 | 0.83 | TTR (0.52) | TTRNSD2NR4A2ALDH1A1CYP3A4 | |
| SCHEMBL28977921 | 0.82 | TTR (0.46) | TTRNSD2AURKAAURKBALDH1A1 | |
| SCHEMBL7729945 | 0.81 | CA1 (0.53) | TTRNSD2ALDH1A1CYP3A4HPGD | |
| Bicarbonate SCHEMBL28267248 | 0.80 | TTR (0.49) | TTRNSD2AURKAAURKBALDH1A1 | |
| SCHEMBL8516378 | 0.79 | TTR (0.66) | TTRNSD2NR4A2ALDH1A1CYP3A4 | |
| SCHEMBL6896171 | 0.79 | ALDH1A1 (0.55) | TTRNSD2SENP3SENP2SENP1 | |
| 3-Aminophenol SCHEMBL28977919 | 0.78 | TDP1 (0.49) | TTRNSD2AURKAAURKBSENP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0865439-A4 | COMBINATORIAL LIBRARIES HAVING AMINODIOL MONOMER SUBUNITS | ISIS PHARMACEUTICALS INC (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0865439-A1 | COMBINATORIAL LIBRARIES HAVING AMINODIOL MONOMER SUBUNITS | ISIS PHARMACEUTICALS, INC. (US) | 1998-09-23 | — | — | EP | disclosed |
| WO-1996040672-A1 | COMBINATORIAL LIBRARIES HAVING AMINODIOL MONOMER SUBUNITS | ISIS PHARMACEUTICALS, INC. (US) | 1996-12-19 | — | — | WO | disclosed |