Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSL | P07711 | 13/20 | 0.52 |
| ▸ | CTSS | P25774 | 13/20 | 0.52 |
| ▸ | CTSK | P43235 | 8/20 | 0.52 |
| ▸ | CTSB | P07858 | 5/20 | 0.50 |
| ▸ | BCHE | P06276 | 2/20 | 0.48 |
| ▸ | ACHE | P22303 | 2/20 | 0.48 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.48 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.48 |
| ▸ | CACNA1S | Q13698 | 1/20 | 0.48 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.48 |
| ▸ | TACR1 | P25103 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2296521 | 0.88 | CTSL (0.55) | CTSLCTSSCTSKCTSBTACR1 | |
| SCHEMBL6947033 | 0.86 | TACR1 (0.53) | CTSLCTSSCTSKCTSBTACR1 | |
| SCHEMBL24853554 | 0.86 | CTSS (0.60) | CTSLCTSSCTSKCTSBTACR1 | |
| SCHEMBL29249016 | 0.86 | CTSS (0.60) | CTSLCTSSCTSKCTSBTACR1 | |
| SCHEMBL16357709 | 0.84 | CTSS (0.67) | CTSLCTSSCTSKCTSBTACR1 | |
| SCHEMBL24629286 | 0.84 | CTSS (0.52) | CTSLCTSSCTSKCTSB | |
| SCHEMBL24852467 | 0.83 | CTSS (0.60) | CTSLCTSSCTSKCTSBTACR1 | |
| SCHEMBL1186365 | 0.83 | CTSS (0.60) | CTSLCTSSCTSKCTSBTACR1 | |
| SCHEMBL29127287 | 0.81 | BCHE (0.58) | CTSLCTSSCTSKBCHEACHE | |
| SCHEMBL715494 | 0.81 | BCHE (0.58) | CTSLCTSSCTSKBCHEACHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756685-A | MEDICAL DIAGNOSIS; THERAPY | NEORX CORPORATION (US) | 1998-05-26 | — | — | US | disclosed |
| US-5625075-A | Metal radionuclide chelating compounds for improved chelation kinetics | NEORX CORPORATION (US) | 1997-04-29 | — | — | US | disclosed |
| US-5556982-A | Metal radionuclide labeled proteins for diagnosis and therapy | NEORX CORPORATION (US) | 1996-09-17 | — | — | US | disclosed |
| US-5436352-A | Metal radionuclide chelating compounds for improved chelation kinetics | NEORX CORPORATION (US) | 1995-07-25 | — | — | US | disclosed |
| US-5242679-A | Complexes for imaging tumors | NEORX CORPORATION (US) | 1993-09-07 | — | — | US | disclosed |
| EP-0344724-B1 | METAL RADIONUCLIDE CHELATING COMPOUNDS FOR IMPROVED CHELATION KINETICS | NEORX CORPORATION (US) | 1993-08-11 | — | — | EP | disclosed |
| US-5175343-A | For detection, radiotherapy and radeoimaging of tumors | NEORX CORPORATION (US) | 1992-12-29 | — | — | US | disclosed |
| US-5120526-A | Chelate compounds | NEORX CORPORATION (US) | 1992-06-09 | — | — | US | disclosed |
| US-5075099-A | Metal radionuclide chelating compounds for improved chelation kinetics | NEORX CORPORATION (US) | 1991-12-24 | — | — | US | disclosed |
| US-5037630-A | Chelated polypeptides specific for tumors, improved imaging | NEORX CORPORATION (US) | 1991-08-06 | — | — | US | disclosed |
| US-4988496-A | Metal radionuclide chelating compounds for improved chelation kinetics | NEORX CORPORATION (US) | 1991-01-29 | — | — | US | disclosed |
| US-4897255-A | Metal radionuclide labeled proteins for diagnosis and therapy | NEORX CORPORATION (US) | 1990-01-30 | — | — | US | disclosed |
| EP-0344724-A2 | Metal radionuclide chelating compounds for improved chelation kinetics | NEORX CORPORATION (US) | 1989-12-06 | — | — | EP | disclosed |
| EP-0300431-A2 | Method of radiolabeling chelating compounds comprising sulfur atoms with metal radionuclides | NEORX CORPORATION (US) | 1989-01-25 | — | — | EP | disclosed |