Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CXCL8 | P10145 | 1/20 | 0.57 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.57 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.57 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.57 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | S1PR5 | Q9H228 | 1/20 | 0.43 |
| ▸ | SLC13A5 | Q86YT5 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | RXRA | P19793 | 4/20 | 0.42 |
| ▸ | RXRB | P28702 | 4/20 | 0.42 |
| ▸ | RXRG | P48443 | 3/20 | 0.42 |
| ▸ | SRD5A2 | P31213 | 1/20 | 0.42 |
| ▸ | KIF11 | P52732 | 1/20 | 0.42 |
| ▸ | SLC6A7 | Q99884 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.40 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.40 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.40 |
| ▸ | PLG | P00747 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8726594 | 0.88 | PTGS2 (0.65) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL7678253 | 0.84 | PTGS2 (0.70) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8458232 | 0.84 | PTGS1 (0.74) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8728872 | 0.80 | PTGS2 (0.70) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8732329 | 0.79 | CXCL8 (0.56) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8729555 | 0.78 | PTGS2 (0.72) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8729441 | 0.78 | PTGS2 (0.91) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8728786 | 0.77 | PTGS2 (0.60) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| Water SCHEMBL11371400 | 0.77 | HPGD (0.57) | CXCL8AKR1B1PTGS1PTGS2GLO1 | |
| SCHEMBL8733799 | 0.77 | PTGS2 (0.70) | CXCL8AKR1B1PTGS1PTGS2GLO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0783488-A4 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO (JP) | 1998-01-07 | — | — | EP | claimed |
| EP-0783488-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1997-07-16 | — | — | EP | claimed |
| WO-1996010013-A1 | FIVE MEMBERED HETEROCYCLIC COMPOUNDS | ONO PHARMACEUTICAL CO., LTD. (JP) | 1996-04-04 | — | — | WO | claimed |