Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2A6 | P11509 | 1/20 | 0.54 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | SLC6A2 | P23975 | 3/20 | 0.49 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.49 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.49 |
| ▸ | HTR2C | P28335 | 2/20 | 0.49 |
| ▸ | HTR2B | P41595 | 2/20 | 0.49 |
| ▸ | HTR7 | P34969 | 1/20 | 0.49 |
| ▸ | HTR3A | P46098 | 1/20 | 0.49 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.49 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.47 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.46 |
| ▸ | CNR1 | P21554 | 2/20 | 0.45 |
| ▸ | CNR2 | P34972 | 2/20 | 0.45 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.45 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.45 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.45 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL433146 | 0.82 | CYP1A2 (0.58) | CYP1A2CYP2A6RAB9ASLC6A2SLC6A4 | |
| SCHEMBL12416670 | 0.78 | CYP1A2 (0.54) | CYP1A2CYP2A6RAB9ASLC6A2SLC6A4 | |
| SCHEMBL241798 | 0.78 | CYP1A2 (0.59) | CYP1A2CYP2A6RAB9ASLC6A2SLC6A4 | |
| SCHEMBL28590608 | 0.78 | CYP2A6 (0.54) | CYP1A2CYP2A6RAB9ASLC6A2SLC6A4 | |
| SCHEMBL1262275 | 0.78 | CYP1A2 (0.54) | CYP1A2CYP2A6RAB9ASLC6A2SLC6A4 | |
| SCHEMBL12187706 | 0.78 | CYP1A2 (0.54) | CYP1A2CYP2A6RAB9ASLC6A2SLC6A4 | |
| SCHEMBL10400372 | 0.78 | RAB9A (0.74) | CYP1A2CYP2A6RAB9ASLC6A2SLC6A3 | |
| SCHEMBL2129850 | 0.78 | CYP1A2 (0.54) | CYP1A2CYP2A6RAB9ASLC6A2SLC6A4 | |
| SCHEMBL1520830 | 0.78 | IDO1 (0.54) | CYP1A2CYP2A6RAB9ASLC6A2SLC6A4 | |
| SCHEMBL915503 | 0.78 | RAB9A (0.50) | CYP1A2CYP2A6RAB9ASLC6A2SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609058-B1 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO CO (JP) | 1998-12-09 | — | — | EP | disclosed |
| US-5491167-A | INHIBITORS OF CHOLESTEROL BIOSYNTHESIS | SANKYO COMPANY, LIMITED (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0609058-A2 | Hexahydronaphthalene ester derivatives, their preparation and their therapeutic uses | SANKYO COMPANY LIMITED (JP) | 1994-08-03 | — | — | EP | disclosed |