SCHEMBL8730727

SCHEMBL8730727

C=Cc1ccc(CCc2ccc(COC)cc2)cc1

nearest known ligand 0.44

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 3/20 0.44
TRPA1 O75762 1/20 0.35
CHRNB2 P17787 1/20 0.35
CHRNB4 P30926 1/20 0.35
CHRNA3 P32297 1/20 0.35
CHRNA7 P36544 1/20 0.35
CHRNA4 P43681 1/20 0.35
TSHR P16473 2/20 0.34
ESR1 P03372 1/20 0.34
ESR2 Q92731 1/20 0.34
HDAC8 Q9BY41 1/20 0.34
TP53 P04637 2/20 0.34
CYP3A4 P08684 1/20 0.34
ALOX15 P16050 1/20 0.34
ALOX12 P18054 1/20 0.34
SMN1; SMN2 Q16637 1/20 0.34
CALM1 P0DP23 2/20 0.33
ABCG2 Q9UNQ0 1/20 0.33
HIF1A Q16665 1/20 0.33
ERN1 O75460 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8732123 0.94 ALDH1A1 (0.39) ALDH1A1TRPA1CHRNB2CHRNB4CHRNA3
SCHEMBL8725590 0.94 ALDH1A1 (0.39) ALDH1A1TRPA1CHRNB2CHRNB4CHRNA3
SCHEMBL91631 0.94 ALDH1A1 (0.50) ALDH1A1TRPA1CHRNB2CHRNB4CHRNA3
SCHEMBL21527137 0.92 CALM1 (0.42) ALDH1A1TRPA1CHRNB2CHRNB4CHRNA3
SCHEMBL5888430 0.88 ALDH1A1 (0.44) ALDH1A1TRPA1CHRNB2CHRNB4CHRNA3
SCHEMBL8728237 0.88 ALDH1A1 (0.44) ALDH1A1TRPA1CHRNB2CHRNB4CHRNA3
SCHEMBL1647493 0.82 ALDH1A1 (0.65) ALDH1A1CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL50012 0.82 ALDH1A1 (0.65) ALDH1A1CHRNB2CHRNB4CHRNA3CHRNA7
SCHEMBL103324 0.82 ALDH1A1 (0.46) ALDH1A1TRPA1CHRNB2CHRNB4CHRNA3
SCHEMBL14340716 0.80 ALDH1A1 (0.57) ALDH1A1TSHRTP53CYP3A4ALOX15

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0882695-A1 BENZYL ETHER DERIVATIVES, LIQUID CRYSTAL COMPOSITION, AND LIQUID CRYSTAL DISPLAY CHISSO CORPORATION (JP) 1998-12-09 EP disclosed