Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Synthalin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 1/20 | 0.70 |
| ▸ | MEN1 | O00255 | 2/20 | 0.67 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.65 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.65 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.65 |
| ▸ | MAOA | P21397 | 1/20 | 0.65 |
| ▸ | MAOB | P27338 | 1/20 | 0.65 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1736310 | 0.94 | DHPS (0.78) | DHPSMEN1KMT2ACYP1A2ALOX15 | |
| Synthalin SCHEMBL9948763 | 0.90 | DHPS (0.74) | DHPSMEN1KMT2ACYP1A2ALOX15 | |
| Hydrochloric Acid SCHEMBL3139421 | 0.90 | DHPS (0.74) | DHPSMEN1KMT2ACYP1A2ALOX15 | |
| Arcaine SCHEMBL1737639 | 0.90 | CYP1A2 (0.77) | DHPSMEN1KMT2ACYP1A2ALOX15 | |
| Dodine SCHEMBL17156887 | 0.87 | MEN1 (0.91) | DHPSMEN1KMT2ACYP1A2ALOX15 | |
| SCHEMBL1736351 | 0.83 | CYP1A2 (0.67) | DHPSMEN1KMT2ACYP1A2ALOX15 | |
| SCHEMBL6700147 | 0.82 | DHPS (1.00) | DHPSMEN1KMT2ACYP1A2ALOX15 | |
| SCHEMBL4099741 | 0.82 | DHPS (0.64) | DHPSMEN1KMT2ACYP1A2ALOX15 | |
| SCHEMBL6693210 | 0.82 | DHPS (1.00) | DHPSMEN1KMT2ACYP1A2ALOX15 | |
| SCHEMBL29454036 | 0.82 | DHPS (1.00) | DHPSMEN1KMT2ACYP1A2ALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240301429-A1 | COMPOSITIONS COMPRISING SASP MODULATORS AND SENESCENCE ATTENUATORS AND USES THEREOF FOR MODULATING CELLULAR SENESCENCE | RSEM, LIMITED PARTNERSHIP (CA) | 2024-09-12 | — | — | US | disclosed |
| US-12031137-B2 | Compositions comprising SASP modulators and senescence attenuators and uses thereof for modulating cellular senescence | RSEM, LIMITED PARTNERSHIP (CA) | 2024-07-09 | — | — | US | disclosed |
| CN-110023332-B | Compositions comprising SASP modulators and senescence attenuating agents and use thereof for modulating cellular senescence | RSEM有限合伙公司 | 2023-09-19 | — | — | CN | disclosed |
| US-20220098594-A1 | COMPOSITIONS COMPRISING SASP MODULATORS AND SENESCENCE ATTENUATORS AND USES THEREOF FOR MODULATING CELLULAR SENESCENCE | RSEM, LIMITED PARTNERSHIP (CA) | 2022-03-31 | — | — | US | disclosed |
| US-20200056186-A1 | COMPOSITIONS COMPRISING SASP MODULATORS AND SENESCENCE ATTENUATORS AND USES THEREOF FOR MODULATING CELLULAR SENESCENCE | CENTRE INTÉGRÉ UNIVERSITAIRE DE SANTÉ ET DE SERVICES SOCIAUX DE L'EST-DE-L'ÎLE-DE-MONTRÉAL (CA) | 2020-02-20 | — | — | US | disclosed |
| CN-110023332-A | Compositions comprising a SASP modulator and a senescence attenuating agent and their use for modulating cellular senescence | RSEM有限合伙公司 | 2019-07-16 | — | — | CN | disclosed |
| EP-2376074-B1 | METHOD FOR IMPROVED BIOACTIVATION OF MEDICATIONS | DRITTE PATENTPORTFOLIO BETEILI (DE) | 2019-03-13 | — | — | EP | disclosed |
| CN-108203878-A | Padding-process antibacterial polyester fabric and preparation method thereof | 青岛祥智电子技术有限公司 | 2018-06-26 | — | — | CN | disclosed |
| CN-107869050-A | Padding-process antibacterial polyester fabric and preparation method thereof | 青岛九洲千和机械有限公司 | 2018-04-03 | — | — | CN | disclosed |
| CN-103668954-B | The antibiotic finishing method of antibacterial finishing agent, fabric and antibiotic fabric | SHANGHAI TAOHONG CHEMICAL TECHNOLOGY CO., LTD. (CN) | 2015-11-25 | — | — | CN | disclosed |
| CN-103668958-B | Impregnation-processantibacterial antibacterial polyester fabric and preparation method thereof | SHANGHAI TAOHONG CHEMICAL TECHNOLOGY CO., LTD. (CN) | 2015-09-16 | — | — | CN | disclosed |
| CN-103668955-B | Padding-process antibacterial polyester fabric and preparation method thereof | SHANGHAI TAOHONG CHEMICAL TECH | 2015-07-15 | — | — | CN | disclosed |
| CN-103668958-A | Impregnation-process antibacterial polyester fabric and preparation method thereof | SHANGHAI TAOHONG CHEMICAL TECH | 2014-03-26 | — | — | CN | disclosed |
| CN-103668954-A | Antibacterial finishing agent, antibacterial finishing method of fabrics, and antibacterial fabrics | SHANGHAI TAOHONG CHEMICAL TECH | 2014-03-26 | — | — | CN | disclosed |
| US-20120077876-A1 | Method For Improved Bioactivation Of Pharmaceuticals | DRITTE PATENTPORTFOLIO BETEILIGUNGSGESELLSCHAFT MBH & CO. KG (DE) | 2012-03-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120077876-A1 | Method For Improved Bioactivation Of Pharmaceuticals | CYP2B6, CYP1A2, CYP2D6 | DHPS 162/4885MEN1 2186/4885KMT2A 3401/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.