SCHEMBL873173

SCHEMBL873173

Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=NC(CC(=O)O)c1nnc(C)n1-2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 20/20 1.00
DNER Q8NFT8 2/20 0.84
BRD2 P25440 6/20 0.82
ADORA3 P0DMS8 1/20 0.81
TSPO P30536 1/20 0.81
BRDT Q58F21 6/20 0.77
BRD3 Q15059 3/20 0.77
CREBBP Q92793 2/20 0.77
HDAC3 O15379 1/20 0.77
JAK2 O60674 1/20 0.77
BRD1 O95696 1/20 0.77
CCL2 P13500 1/20 0.77
HDAC4 P56524 1/20 0.77
EP300 Q09472 1/20 0.77
HDAC1 Q13547 1/20 0.77
HDAC7 Q8WUI4 1/20 0.77
HDAC2 Q92769 1/20 0.77
HDAC10 Q969S8 1/20 0.77
HDAC11 Q96DB2 1/20 0.77
HDAC8 Q9BY41 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL881274 1.00 BRD4 (1.00) BRD4DNERBRD2ADORA3TSPO
SCHEMBL7480681 1.00 BRD4 (1.00) BRD4DNERBRD2ADORA3TSPO
Hydrochloric Acid SCHEMBL15900115 0.99 BRD4 (0.98) BRD4DNERBRD2ADORA3TSPO
Hydrochloric Acid SCHEMBL15900132 0.99 BRD4 (0.98) BRD4DNERBRD2ADORA3TSPO
SCHEMBL16150161 0.94 BRD4 (0.93) BRD4DNERBRD2ADORA3TSPO
SCHEMBL15980842 0.92 BRD4 (1.00) BRD4DNERBRD2ADORA3TSPO
SCHEMBL19556888 0.92 BRD4 (1.00) BRD4DNERBRD2ADORA3TSPO
SCHEMBL18017604 0.92 BRD4 (1.00) BRD4DNERBRD2ADORA3TSPO
SCHEMBL12228129 0.92 BRD4 (0.85) BRD4DNERBRD2ADORA3TSPO
SCHEMBL21501421 0.91 BRD4 (0.84) BRD4DNERBRD2ADORA3TSPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 122 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-10668017-B2 Perivascular drug delivery system WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2020-06-02 US claimed
US-20180042844-A1 PERIVASCULAR DRUG DELIVERY SYSTEM NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2018-02-15 US claimed
EP-3268007-A1 COMPOSITIONS AND THERAPEUTIC METHODS FOR THE TREATMENT OF COMPLEMENT-ASSOCIATED DISEASES Resverlogix Corp. (CA) 2018-01-17 EP claimed
WO-2016179222-A1 ZNF532 FOR DIAGNOSIS AND TREATMENT OF CANCER THE BRIGHAM AND WOMEN'S HOSPITAL, INC. (US) 2016-11-10 WO claimed
WO-2016147053-A1 COMPOSITIONS AND THERAPEUTIC METHODS FOR THE TREATMENT OF COMPLEMENT-ASSOCIATED DISEASES RESVERLOGIX CORP. (CA) 2016-09-22 WO claimed
US-20250367214-A1 COMPOUNDS AND METHODS FOR MODULATING FRATAXIN EXPRESSION WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2025-12-04 US disclosed
EP-4608876-A2 ENDOCYTIC AGENTS BioVentures, LLC (US) 2025-09-03 EP disclosed
US-20250262309-A1 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOSITIONS USING UBIQUITIN CONJUGATING ENZYME LIGANDS BERG, KARA ANN 2025-08-21 US disclosed
EP-3436006-B1 METHODS AND COMPOSITIONS FOR MODULATING FRATAXIN EXPRESSION WISCONSIN ALUMNI RES FOUND (US) 2025-07-30 EP disclosed
US-20250136619-A1 HETEROBIFUNCTIONAL COMPOUNDS AND THEIR USE IN TREATING DISEASE HALDA THERAPEUTICS OPCO, INC. 2025-05-01 US disclosed
WO-2025076057-A1 SELECTIVE INHIBITION OF MDM2-AMPLIFIED CANCERS USING TARGETED PROTEIN DEGRADERS DANA-FARBER CANCER INSTITUTE, INC. (US) 2025-04-10 WO disclosed
CN-119546341-A Proteolytic targeting chimeric (PROTAC) compositions using ubiquitin conjugated enzyme ligands 布普格生物制药公司 2025-02-28 CN disclosed
WO-2011143651-A1 COMPOSITIONS AND METHODS FOR MODULATING METABOLISM DANA-FARBER CANCER INSTITUTE, INC. (US) 2011-11-17 WO disclosed
WO-2011143651-A1 COMPOSITIONS AND METHODS FOR MODULATING METABOLISM DANA-FARBER CANCER INSTITUTE, INC. (US) 2011-11-17 WO disclosed
WO-2011143657-A1 MALE CONTRACEPTIVE COMPOSITIONS AND METHODS OF USE DANA-FARBER CANCER INSTITUTE, INC. (US) 2011-11-17 WO disclosed
WO-2011143657-A1 MALE CONTRACEPTIVE COMPOSITIONS AND METHODS OF USE DANA-FARBER CANCER INSTITUTE, INC. (US) 2011-11-17 WO disclosed
WO-2011143660-A2 COMPOSITIONS AND METHODS FOR TREATING LEUKEMIA DANA-FARBER CANCER INSTITUTE, INC. (US) 2011-11-17 WO disclosed
WO-2011143660-A2 COMPOSITIONS AND METHODS FOR TREATING LEUKEMIA DANA-FARBER CANCER INSTITUTE, INC. (US) 2011-11-17 WO disclosed
EP-0989131-B1 THIENOTRIAZOLODIAZEPINE COMPOUNDS AND MEDICINAL USES THEREOF MITSUBISHI PHARMA CORP (JP) 2002-11-13 EP disclosed
EP-0989131-A1 THIENOTRIAZOLODIAZEPINE COMPOUNDS AND MEDICINAL USES THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2000-03-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20250262309-A1 PROTEOLYSIS TARGETING CHIMERA (PROTAC) COMPOSITIONS USING UBIQUITIN CONJUGATING ENZYME LIGANDS UBE3C, UBE3A, MDM2 BRD4 2044/4885DNER 1250/4885BRD2 991/4885
US-20250136619-A1 HETEROBIFUNCTIONAL COMPOUNDS AND THEIR USE IN TREATING DISEASE CDK9, AURKB, AURKC BRD4 90/4885DNER 672/4885BRD2 460/4885
US-20250367214-A1 COMPOUNDS AND METHODS FOR MODULATING FRATAXIN EXPRESSION BRD4, BICRA, BRDT BRD4 1/4885DNER 1293/4885BRD2 9/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.