SCHEMBL7480681

SCHEMBL7480681

Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@H](CC(=O)O)c1nnc(C)n1-2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 20/20 1.00
DNER Q8NFT8 2/20 0.84
BRD2 P25440 6/20 0.82
ADORA3 P0DMS8 1/20 0.81
TSPO P30536 1/20 0.81
BRDT Q58F21 6/20 0.77
BRD3 Q15059 3/20 0.77
CREBBP Q92793 2/20 0.77
HDAC3 O15379 1/20 0.77
JAK2 O60674 1/20 0.77
BRD1 O95696 1/20 0.77
CCL2 P13500 1/20 0.77
HDAC4 P56524 1/20 0.77
EP300 Q09472 1/20 0.77
HDAC1 Q13547 1/20 0.77
HDAC7 Q8WUI4 1/20 0.77
HDAC2 Q92769 1/20 0.77
HDAC10 Q969S8 1/20 0.77
HDAC11 Q96DB2 1/20 0.77
HDAC8 Q9BY41 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL873173 1.00 BRD4 (1.00) BRD4DNERBRD2ADORA3TSPO
SCHEMBL881274 1.00 BRD4 (1.00) BRD4DNERBRD2ADORA3TSPO
Hydrochloric Acid SCHEMBL15900115 0.99 BRD4 (0.98) BRD4DNERBRD2ADORA3TSPO
Hydrochloric Acid SCHEMBL15900132 0.99 BRD4 (0.98) BRD4DNERBRD2ADORA3TSPO
SCHEMBL16150161 0.94 BRD4 (0.93) BRD4DNERBRD2ADORA3TSPO
SCHEMBL15980842 0.92 BRD4 (1.00) BRD4DNERBRD2ADORA3TSPO
SCHEMBL19556888 0.92 BRD4 (1.00) BRD4DNERBRD2ADORA3TSPO
SCHEMBL18017604 0.92 BRD4 (1.00) BRD4DNERBRD2ADORA3TSPO
SCHEMBL12228129 0.92 BRD4 (0.85) BRD4DNERBRD2ADORA3TSPO
SCHEMBL21501421 0.91 BRD4 (0.84) BRD4DNERBRD2ADORA3TSPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 110 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2026107406-A1 p53 HETEROBIFUNCTIONAL CONJUGATES AND USES THEREOF Design Therapeutics, Inc. (US) 2026-05-21 WO disclosed
US-20250327028-A1 ENGINEERED PLATELETS AS TARGETED PROTEIN DEGRADERS WISCONSIN ALUMNI RESEARCH FOUNDATION (US) 2025-10-23 US disclosed
EP-4629984-A1 DEVELOPMENT OF POTENT DUAL HDAC/BRD4 INHIBITORS BioVentures, LLC (US) 2025-10-15 EP disclosed
EP-4608876-A2 ENDOCYTIC AGENTS BioVentures, LLC (US) 2025-09-03 EP disclosed
US-20250129125-A1 MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2025-04-24 US disclosed
WO-2025076236-A1 METHODS AND COMPOUNDS FOR MODULATING HUNTINGTON'S DISEASE Design Therapeutics, Inc. (US) 2025-04-10 WO disclosed
WO-2025076181-A1 METHODS AND COMPOUNDS FOR MODULATING HUNTINGTON'S DISEASE Design Therapeutics, Inc. (US) 2025-04-10 WO disclosed
WO-2025076219-A1 METHODS AND COMPOUNDS FOR MODULATING HUNTINGTON'S DISEASE Design Therapeutics, Inc. (US) 2025-04-10 WO disclosed
US-20240239818-A1 COMPOUNDS AND COMPOSITIONS COMPRISING FLUOROPHORES FOR USE IN VISUALIZATION AND PURIFICATION OR MANIPULATION HOWARD HUGHES MEDICAL INSTITUTE 2024-07-18 US disclosed
US-20240239818-A1 COMPOUNDS AND COMPOSITIONS COMPRISING FLUOROPHORES FOR USE IN VISUALIZATION AND PURIFICATION OR MANIPULATION HOWARD HUGHES MEDICAL INSTITUTE 2024-07-18 US disclosed
US-20140011862-A1 Compositions and Methods for Treating Leukemia COLD SPRING HARBOR LABORATORY (US) 2014-01-09 US disclosed
US-20130252331-A1 COMPOSITIONS AND METHODS FOR MODULATING METABOLISM NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2013-09-26 US disclosed
US-20130252331-A1 COMPOSITIONS AND METHODS FOR MODULATING METABOLISM NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT 2013-09-26 US disclosed
US-20130210813-A1 Male Contraceptive Compositions and Methods of Use DANA-FARBER CANCER INSTITUTE, INC. 2013-08-15 US disclosed
US-20130210813-A1 Male Contraceptive Compositions and Methods of Use DANA-FARBER CANCER INSTITUTE, INC. 2013-08-15 US disclosed
WO-2011143651-A1 COMPOSITIONS AND METHODS FOR MODULATING METABOLISM DANA-FARBER CANCER INSTITUTE, INC. (US) 2011-11-17 WO disclosed
WO-2011143657-A1 MALE CONTRACEPTIVE COMPOSITIONS AND METHODS OF USE DANA-FARBER CANCER INSTITUTE, INC. (US) 2011-11-17 WO disclosed
WO-2011143660-A2 COMPOSITIONS AND METHODS FOR TREATING LEUKEMIA DANA-FARBER CANCER INSTITUTE, INC. (US) 2011-11-17 WO disclosed
EP-0989131-B1 THIENOTRIAZOLODIAZEPINE COMPOUNDS AND MEDICINAL USES THEREOF MITSUBISHI PHARMA CORP (JP) 2002-11-13 EP disclosed
EP-0989131-A1 THIENOTRIAZOLODIAZEPINE COMPOUNDS AND MEDICINAL USES THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2000-03-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20240239818-A1 COMPOUNDS AND COMPOSITIONS COMPRISING FLUOROPHORES FOR USE IN VISUALIZATION AND PURIFICATION OR MANIPULATION STAMBP, MSN, SYPL1 BRD4 1296/4885DNER 3560/4885BRD2 3112/4885
US-20250129125-A1 MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF PAICS, CYCS, LSS BRD4 537/4885DNER 2335/4885BRD2 2140/4885
US-20130210813-A1 Male Contraceptive Compositions and Methods of Use SHBG, CYP19A1, CYP17A1 BRD4 3192/4885DNER 2524/4885BRD2 4023/4885
US-20140011862-A1 Compositions and Methods for Treating Leukemia MCL1, ABL1, FLT3 BRD4 891/4885DNER 840/4885BRD2 1481/4885
US-20250327028-A1 ENGINEERED PLATELETS AS TARGETED PROTEIN DEGRADERS HSP90B1, HSP90AB1, HSP90AA1 BRD4 3402/4885DNER 4031/4885BRD2 3340/4885
US-20130252331-A1 COMPOSITIONS AND METHODS FOR MODULATING METABOLISM BRD3, BRD2, BRD4 BRD4 3/4885DNER 2719/4885BRD2 2/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.