SCHEMBL881274

SCHEMBL881274

Cc1sc2c(c1C)C(c1ccc(Cl)cc1)=N[C@@H](CC(=O)O)c1nnc(C)n1-2

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BRD4 O60885 20/20 1.00
DNER Q8NFT8 2/20 0.84
BRD2 P25440 6/20 0.82
ADORA3 P0DMS8 1/20 0.81
TSPO P30536 1/20 0.81
BRDT Q58F21 6/20 0.77
BRD3 Q15059 3/20 0.77
CREBBP Q92793 2/20 0.77
HDAC3 O15379 1/20 0.77
JAK2 O60674 1/20 0.77
BRD1 O95696 1/20 0.77
CCL2 P13500 1/20 0.77
HDAC4 P56524 1/20 0.77
EP300 Q09472 1/20 0.77
HDAC1 Q13547 1/20 0.77
HDAC7 Q8WUI4 1/20 0.77
HDAC2 Q92769 1/20 0.77
HDAC10 Q969S8 1/20 0.77
HDAC11 Q96DB2 1/20 0.77
HDAC8 Q9BY41 1/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL873173 1.00 BRD4 (1.00) BRD4DNERBRD2ADORA3TSPO
SCHEMBL7480681 1.00 BRD4 (1.00) BRD4DNERBRD2ADORA3TSPO
Hydrochloric Acid SCHEMBL15900115 0.99 BRD4 (0.98) BRD4DNERBRD2ADORA3TSPO
Hydrochloric Acid SCHEMBL15900132 0.99 BRD4 (0.98) BRD4DNERBRD2ADORA3TSPO
SCHEMBL16150161 0.94 BRD4 (0.93) BRD4DNERBRD2ADORA3TSPO
SCHEMBL15980842 0.92 BRD4 (1.00) BRD4DNERBRD2ADORA3TSPO
SCHEMBL19556888 0.92 BRD4 (1.00) BRD4DNERBRD2ADORA3TSPO
SCHEMBL18017604 0.92 BRD4 (1.00) BRD4DNERBRD2ADORA3TSPO
SCHEMBL12228129 0.92 BRD4 (0.85) BRD4DNERBRD2ADORA3TSPO
SCHEMBL21501421 0.91 BRD4 (0.84) BRD4DNERBRD2ADORA3TSPO

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 715 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3468559-B1 METHODS OF USE AND PHARMACEUTICAL COMBINATIONS OF HDAC INHIBITORS WITH BET INHIBITORS DANA FARBER CANCER INST INC (US) 2023-11-22 EP claimed
US-20230310452-A1 BROMODOMAIN AND EXTRA TERMINAL DOMAIN (BET) INHIBITOR COMPOSITIONS AND METHODS THEREOF FOR USE AS ANTI-AGING AGENTS MDI BIOLOGICAL LABORATORY (US) 2023-10-05 US claimed
CN-116510024-A Composition, preparation method and application thereof 上海复东生物医药有限责任公司 2023-08-01 CN claimed
EP-4168121-A2 MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF Genentech, Inc. (US) 2023-04-26 EP claimed
US-11298354-B2 Methods of use and pharmaceutical combinations of HDAC inhibitors with BET inhibitors DANA-FARBER CANCER INSTITUTE, INC. (US) 2022-04-12 US claimed
WO-2022046682-A1 BROMODOMAIN AND EXTRA TERMINAL DOMAIN (BET) INHIBITOR COMPOSITIONS AND METHODS THEREOF FOR USE AS ANTI-AGING AGENTS MDI BIOLOGICAL LABORATORY (US) 2022-03-03 WO claimed
WO-2021262731-A2 MACROCYCLIC COMPOUNDS AND METHODS OF USE THEREOF GENENTECH, INC. (US) 2021-12-30 WO claimed
US-20260109707-A1 HETEROBIFUNCTIONAL COMPOUNDS AND METHODS OF TREATING DISEASE HALDA THERAPEUTICS OPCO INC (US) 2026-04-23 US disclosed
US-12605450-B2 C3-carbon linked glutarimide Degronimers for target protein degradation C4 THERAPEUTICS, INC. (US) 2026-04-21 US disclosed
US-20260098043-A1 POLYCYCLIC COMPOUND AND USE THEREOF HAINAN SIMCERE ZAIMING PHARMECEUTICAL CO LTD (CN) 2026-04-09 US disclosed
EP-4720058-A2 BIFUNCTIONAL DEGRADERS AND USES THEREOF Casma Therapeutics, Inc. (US) 2026-04-08 EP disclosed
EP-4717317-A2 N/O-LINKED DEGRONS AND DEGRONIMERS FOR PROTEIN DEGRADATION C4 Therapeutics, Inc. (US) 2026-04-01 EP disclosed
US-20260085075-A1 PROTEIN DEGRADERS AND USES THEREOF KYMERA THERAPEUTICS INC (US) 2026-03-26 US disclosed
WO-2011143657-A1 MALE CONTRACEPTIVE COMPOSITIONS AND METHODS OF USE DANA-FARBER CANCER INSTITUTE, INC. (US) 2011-11-17 WO disclosed
WO-2011143651-A1 COMPOSITIONS AND METHODS FOR MODULATING METABOLISM DANA-FARBER CANCER INSTITUTE, INC. (US) 2011-11-17 WO disclosed
US-8044042-B2 Thienotriazolodiazepine compound and medicinal use thereof MITSUBISHI TANABE PHARMA CORPORATION (JP) 2011-10-25 US disclosed
US-20100041643-A1 THIENOTRIAZOLODIAZEPINE COMPOUND AND MEDICINAL USE THEREOF MITSUBISHI TANABE PHARMA CORPORATION (JP) 2010-02-18 US disclosed
EP-1887008-A1 THIENOTRIAZOLODIAZEPINE COMPOUND AND A MEDICINAL USE THEREOF Mitsubishi Tanabe Pharma Corporation (JP) 2008-02-13 EP disclosed
EP-0989131-B1 THIENOTRIAZOLODIAZEPINE COMPOUNDS AND MEDICINAL USES THEREOF MITSUBISHI PHARMA CORP (JP) 2002-11-13 EP disclosed
EP-0989131-A1 THIENOTRIAZOLODIAZEPINE COMPOUNDS AND MEDICINAL USES THEREOF YOSHITOMI PHARMACEUTICAL INDUSTRIES, LTD. (JP) 2000-03-29 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-12605450-B2 C3-carbon linked glutarimide Degronimers for target protein degradation NEDD4, UBE3A, UBE3C BRD4 1630/4885DNER 257/4885BRD2 1196/4885
US-20260098043-A1 POLYCYCLIC COMPOUND AND USE THEREOF H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16, NR3C2, NR3C1 BRD4 205/4885DNER 3101/4885BRD2 333/4885
US-20100041643-A1 THIENOTRIAZOLODIAZEPINE COMPOUND AND MEDICINAL USE THEREOF ICOS, CD4, CD2 BRD4 265/4885DNER 3109/4885BRD2 318/4885
US-11298354-B2 Methods of use and pharmaceutical combinations of HDAC inhibitors with BET inhibitors HDAC9, HDAC7, HDAC8 BRD4 15/4885DNER 2588/4885BRD2 30/4885
US-20260109707-A1 HETEROBIFUNCTIONAL COMPOUNDS AND METHODS OF TREATING DISEASE BRD4, AR, BRDT BRD4 1/4885DNER 1376/4885BRD2 11/4885
US-20260085075-A1 PROTEIN DEGRADERS AND USES THEREOF NR2C2, SRR, NCOR2 BRD4 902/4885DNER 1102/4885BRD2 584/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.