Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | MGLL | Q99685 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 2/20 | 0.37 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10119355 | 0.97 | LMNA (0.42) | LMNAL3MBTL1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL10119362 | 0.91 | HPGD (0.48) | ALDH1A1SMN1; SMN2KMT2ANPC1RAB9A | |
| SCHEMBL872107 | 0.89 | KMT2A (0.42) | LMNAL3MBTL1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL845120 | 0.76 | HPGD (0.47) | LMNAL3MBTL1ALDH1A1KMT2ANPC1 | |
| SCHEMBL845476 | 0.73 | HPGD (0.46) | LMNAL3MBTL1ALDH1A1KMT2ANPC1 | |
| SCHEMBL873304 | 0.72 | PFKFB3 (0.39) | — | |
| SCHEMBL872441 | 0.72 | HPGD (0.38) | LMNAALDH1A1SMN1; SMN2KMT2ANPC1 | |
| SCHEMBL845500 | 0.71 | HPGD (0.51) | LMNAL3MBTL1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL845495 | 0.71 | HPGD (0.51) | LMNAL3MBTL1ALDH1A1SMN1; SMN2KMT2A | |
| SCHEMBL844884 | 0.70 | HTT (0.48) | LMNAALDH1A1KMT2AHTTNPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143288-B2 | Inhibitors of HCV replication | BRISTOL-MYERS SQUIBB COMPANY (US) | 2012-03-27 | — | — | US | disclosed |