Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | F2RL3 | Q96RI0 | 2/20 | 0.32 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | DPP4 | P27487 | 1/20 | 0.30 |
| ▸ | XDH | P47989 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8728241 | 0.77 | POLB (0.40) | MAPTTP53NPC1ALDH1A1RAB9A | |
| SCHEMBL7372881 | 0.76 | TP53 (0.37) | MAPTTP53GAADPP4 | |
| SCHEMBL8731806 | 0.74 | LMNA (0.57) | MAPTTP53NPC1ALDH1A1HTT | |
| SCHEMBL7369292 | 0.74 | MAPT (0.45) | MAPTTP53GAAALDH1A1XDH | |
| SCHEMBL7367777 | 0.72 | MAPT (0.54) | MAPTTP53GAANPC1ALDH1A1 | |
| SCHEMBL7371022 | 0.70 | TDP1 (0.47) | MAPTALDH1A1HTTSMN1; SMN2 | |
| SCHEMBL7369595 | 0.69 | HPGD (0.46) | MAPTTP53GAAALDH1A1HTT | |
| SCHEMBL7367916 | 0.66 | MMP2 (0.40) | MAPTTP53GAANPC1ALDH1A1 | |
| SCHEMBL8726194 | 0.66 | PIK3CA (0.43) | MAPTNPC1ALDH1A1HTTRAB9A | |
| SCHEMBL7435351 | 0.66 | TPMT (0.41) | HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5705703-A | ENZYME INHIBITORS OF TRANSFERASES | HOFFMANN-LA ROCHE INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5633371-A | ENZYME INHIBITORS; TREATMENT OF DEPRESSION AND PARKINSON*S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5476875-A | Catechol derivatives | HOFFMAN-LA ROCHE INC. (US) | 1995-12-19 | — | — | US | disclosed |
| US-5389653-A | Inhibitors of the enzyme catechol-O-methyltransferase; useful as co-medication in treatment of Parkinson's disease | HOFFMAN-LA ROCHE INC. (US) | 1995-02-14 | — | — | US | disclosed |
| US-5236952-A | Inhibit the enzyme catechol-O-methyltransferase; for treatment of Parkinson's disease administered with L-dopa | HOFFMANN-LA ROCHE INC. (US) | 1993-08-17 | — | — | US | disclosed |