Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.37 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7367277 | 0.78 | MET (0.40) | POLBRAB9ASMN1; SMN2LMNATP53 | |
| SCHEMBL7365147 | 0.77 | FLT3 (0.42) | POLBRAB9ASMN1; SMN2LMNATP53 | |
| SCHEMBL8733137 | 0.77 | MAPT (0.40) | RAB9ASMN1; SMN2TP53MAPTNPC1 | |
| SCHEMBL11012268 | 0.77 | MAPT (0.46) | POLBRAB9ASMN1; SMN2LMNATP53 | |
| SCHEMBL7369595 | 0.75 | HPGD (0.46) | RAB9ATP53MAPTALDH1A1 | |
| SCHEMBL7367777 | 0.74 | MAPT (0.54) | RAB9ASMN1; SMN2LMNATP53MAPT | |
| SCHEMBL11004327 | 0.71 | CASP3 (0.53) | RAB9ASMN1; SMN2LMNATP53MAPT | |
| SCHEMBL73916 | 0.71 | MBD2 (0.58) | RAB9ASMN1; SMN2LMNATP53MAPT | |
| SCHEMBL8726194 | 0.70 | PIK3CA (0.43) | RAB9ASMN1; SMN2LMNAMAPTTSHR | |
| SCHEMBL11005976 | 0.69 | TP53 (0.55) | POLBRAB9ASMN1; SMN2LMNATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5705703-A | ENZYME INHIBITORS OF TRANSFERASES | HOFFMANN-LA ROCHE INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5633371-A | ENZYME INHIBITORS; TREATMENT OF DEPRESSION AND PARKINSON*S DISEASE | HOFFMANN-LA ROCHE INC. (US) | 1997-05-27 | — | — | US | disclosed |
| US-5476875-A | Catechol derivatives | HOFFMAN-LA ROCHE INC. (US) | 1995-12-19 | — | — | US | disclosed |
| US-5389653-A | Inhibitors of the enzyme catechol-O-methyltransferase; useful as co-medication in treatment of Parkinson's disease | HOFFMAN-LA ROCHE INC. (US) | 1995-02-14 | — | — | US | disclosed |
| US-5236952-A | Inhibit the enzyme catechol-O-methyltransferase; for treatment of Parkinson's disease administered with L-dopa | HOFFMANN-LA ROCHE INC. (US) | 1993-08-17 | — | — | US | disclosed |