SCHEMBL8733579

SCHEMBL8733579

COc1cc(OC)nc(N(C(N)=O)S(=O)(=O)c2c(Cl)nc3ccccn23)n1

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SMN1; SMN2 Q16637 5/20 0.41
RAB9A P51151 4/20 0.41
MAPK1 P28482 3/20 0.41
ALDH1A1 P00352 3/20 0.39
LMNA P02545 1/20 0.39
MAPT P10636 4/20 0.38
DAPK3 O43293 1/20 0.37
JAK2 O60674 1/20 0.37
PRKD3 O94806 1/20 0.37
MAP4K4 O95819 1/20 0.37
ABL1 P00519 1/20 0.37
CSF1R P07333 1/20 0.37
RET P07949 1/20 0.37
MET P08581 1/20 0.37
PDGFRA P16234 1/20 0.37
PRKACA P17612 1/20 0.37
LTK P29376 1/20 0.37
GRK5 P34947 1/20 0.37
KDR P35968 1/20 0.37
MAPK8 P45983 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8175077 0.86 KMT2A (0.37) SMN1; SMN2MAPK1ALDH1A1LMNAMAPT
SCHEMBL55236 0.74 GAA (0.52) SMN1; SMN2RAB9AMAPK1ALDH1A1MAPT
SCHEMBL8535700 0.74 GAA (0.52) SMN1; SMN2RAB9AMAPK1ALDH1A1MAPT
SCHEMBL730603 0.74 ALDH1A1 (0.35) SMN1; SMN2ALDH1A1LMNAKDM4EHPGD
SCHEMBL9247051 0.73 SMN1; SMN2 (0.35) SMN1; SMN2ALDH1A1LMNAMAPTKDM4E
SCHEMBL9517874 0.71 MAPT (0.45) SMN1; SMN2RAB9AMAPK1ALDH1A1LMNA
SCHEMBL28716152 0.71 SMN1; SMN2 (0.38) SMN1; SMN2ALDH1A1LMNAMAPTKDM4E
SCHEMBL4280858 0.70 SMN1; SMN2 (0.43) SMN1; SMN2ALDH1A1MAPTKDM4ENPSR1
SCHEMBL27290280 0.70 SMN1; SMN2 (0.64) SMN1; SMN2ALDH1A1MAPTKDM4ENPSR1
SCHEMBL9362818 0.70 KDM4E (0.54) SMN1; SMN2RAB9AMAPK1ALDH1A1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0708597-B1 HERBICIDAL COMPOSITIONS RHONE POULENC AGROCHIMIE (FR) 1998-09-16 EP claimed
US-5672566-A MIXTURES OF 6-ALKYL-3-ALKYL(OR HALOALKYL-)PHENYL-5-PHENYL 2,3-DIHYDRO-4H-1,3-OXAZIN-4-ONES WITH OTHER HERBICIDES RHONE-POULENC AGROCHIMIE (FR) 1997-09-30 US claimed
EP-0708597-A1 HERBICIDAL COMPOSITIONS RHONE-POULENC AGROCHIMIE (FR) 1996-05-01 EP claimed
WO-1995002329-A1 HERBICIDAL COMPOSITIONS RHONE-POULENC AGROCHIMIE (FR) 1995-01-26 WO claimed
JP-7025711-A None JP disclosed
EP-0708597-B1 HERBICIDAL COMPOSITIONS RHONE POULENC AGROCHIMIE (FR) 1998-09-16 EP disclosed
US-5672566-A MIXTURES OF 6-ALKYL-3-ALKYL(OR HALOALKYL-)PHENYL-5-PHENYL 2,3-DIHYDRO-4H-1,3-OXAZIN-4-ONES WITH OTHER HERBICIDES RHONE-POULENC AGROCHIMIE (FR) 1997-09-30 US disclosed
JP-H0725711-A HERBICIDAL COMPOSITION MITSUBISHI CHEM CORP 1995-01-27 JP disclosed
JP-H00725711-A 0001-01-01 JP disclosed