Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.50 |
| ▸ | CA2 | P00918 | 2/20 | 0.50 |
| ▸ | CA7 | P43166 | 2/20 | 0.50 |
| ▸ | CA9 | Q16790 | 2/20 | 0.50 |
| ▸ | SRD5A1 | P18405 | 2/20 | 0.36 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.35 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.35 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.34 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.34 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.33 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.33 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
| ▸ | WRN | Q14191 | 1/20 | 0.30 |
| ▸ | MAPT | P10636 | 1/20 | 0.30 |
| ▸ | RECQL | P46063 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8599479 | 0.70 | CA1 (0.46) | CA1CA2CA7CA9SRD5A1 | |
| SCHEMBL14939549 | 0.70 | MAPT (0.52) | CA1CA2CA7CA9SRD5A1 | |
| SCHEMBL14939600 | 0.68 | CA1 (0.57) | CA1CA2CA7CA9AKR1A1 | |
| SCHEMBL22129686 | 0.67 | CA1 (0.48) | CA1CA2CA7CA9AKR1A1 | |
| SCHEMBL8665649 | 0.67 | CA1 (1.00) | CA1CA2CA7CA9AKR1A1 | |
| SCHEMBL31722364 | 0.64 | SRD5A1 (0.47) | CA1CA2CA7CA9SRD5A1 | |
| SCHEMBL5866470 | 0.64 | CA1 (0.52) | CA1CA2CA7CA9AKR1A1 | |
| SCHEMBL13487412 | 0.64 | CA1 (0.52) | CA1CA2CA7CA9AKR1A1 | |
| SCHEMBL10716838 | 0.64 | MAOA (0.52) | CA1CA2CA7CA9AKR1A1 | |
| SCHEMBL14939579 | 0.62 | SRD5A1 (0.36) | CA1CA2CA7CA9SRD5A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0876356-A1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | LABORATOIRE INNOTHERA Société Anonyme (FR) | 1998-11-11 | — | — | EP | disclosed |
| WO-1997021684-A1 | USE OF TRICYCLIC 1,4-DIHYDRO-1,4-DIOXO-1H-NAPHTHALENE DERIVATIVES, RESULTING NOVEL COMPOUNDS AND THERAPEUTICAL USE THEREOF | LABORATOIRE INNOTHERA, SOCIETE ANONYME (FR) | 1997-06-19 | — | — | WO | disclosed |