Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.48 |
| ▸ | CA1 | P00915 | 6/20 | 0.41 |
| ▸ | CA2 | P00918 | 6/20 | 0.41 |
| ▸ | CA12 | O43570 | 5/20 | 0.41 |
| ▸ | CA9 | Q16790 | 5/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.39 |
| ▸ | IDO1 | P14902 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.38 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8733836 | 0.82 | ACACB (0.45) | PTPN1 | |
| SCHEMBL27741033 | 0.76 | ACACB (0.59) | NAMPTCA1CA2CA12CA9 | |
| SCHEMBL8732412 | 0.75 | CA2 (0.47) | NAMPTCA1CA2CA12CA9 | |
| SCHEMBL1541945 | 0.75 | CA1 (0.64) | NAMPTCA1CA2CA12CA9 | |
| SCHEMBL8757517 | 0.74 | CA2 (0.53) | NAMPTCA1CA2CA12CA9 | |
| SCHEMBL8729156 | 0.74 | NAMPT (0.42) | NAMPTCA1CA2CA12CA9 | |
| SCHEMBL4446760 | 0.74 | MEN1 (0.55) | NAMPTCA1CA2CA12CA9 | |
| SCHEMBL3004957 | 0.74 | FFAR1 (0.55) | NAMPTIDO1KMT2AMAPTNPC1 | |
| SCHEMBL26964370 | 0.74 | CA1 (0.56) | NAMPTCA1CA2CA12CA9 | |
| SCHEMBL19003451 | 0.74 | ACACB (0.61) | NAMPTCA1CA2CA12CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5726165-A | HYPOGLYCEMIC AGENTS; DIETETICS; GASTROINTESTINAL DISORDERS | SMITHKLINE BEECHAM P.L.C. (GB) | 1998-03-10 | — | — | US | disclosed |