SCHEMBL8734852

SCHEMBL8734852

CSc1cccc(C)c1S(=O)(=O)OC[PH](=O)O

nearest known ligand 0.35

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
LMNA P02545 2/20 0.35
MAPT P10636 2/20 0.33
L3MBTL1 Q9Y468 2/20 0.33
ALDH1A1 P00352 2/20 0.33
TDP1 Q9NUW8 1/20 0.33
TSHR P16473 1/20 0.30
KMT2A Q03164 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8729862 0.89
SCHEMBL8734593 0.86 GAA (0.32) MAPTL3MBTL1
SCHEMBL8731808 0.85 LMNA (0.32) LMNAMAPTL3MBTL1ALDH1A1
SCHEMBL8732662 0.85 KDM4E (0.32)
SCHEMBL8734846 0.84 FFAR4 (0.33) LMNASMN1; SMN2
SCHEMBL8731880 0.84
SCHEMBL8854550 0.84 LMNA (0.34) LMNAMAPTL3MBTL1ALDH1A1TDP1
SCHEMBL8729877 0.82 STK10 (0.33)
SCHEMBL27465920 0.81 LMNA (0.33) LMNAMAPTL3MBTL1ALDH1A1TDP1
SCHEMBL8734771 0.80 SLC40A1 (0.35) LMNAALDH1A1TSHRKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0699390-B1 Compositions containing phosphosulfonate herbicides and dichloroacetamide safeners, and method of use ROHM & HAAS (US) 1998-10-07 EP claimed
EP-0699390-A2 Compositions containing phosphosulfonate herbicides and dichloroacetamide safeners, and method of use ROHM AND HAAS COMPANY (US) 1996-03-06 EP claimed
EP-0699390-B1 Compositions containing phosphosulfonate herbicides and dichloroacetamide safeners, and method of use ROHM & HAAS (US) 1998-10-07 EP disclosed
EP-0699390-A2 Compositions containing phosphosulfonate herbicides and dichloroacetamide safeners, and method of use ROHM AND HAAS COMPANY (US) 1996-03-06 EP disclosed