Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | USP2 | O75604 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | CASP1 | P29466 | 1/20 | 0.40 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.40 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL874041 | 0.80 | MAPK1 (0.39) | RECQLTSHRKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL864133 | 0.76 | SMN1; SMN2 (0.40) | ALDH1A1SMN1; SMN2MAPK1KDM4E | |
| SCHEMBL874538 | 0.74 | MEN1 (0.47) | KMT2AALDH1A1SMN1; SMN2MEN1USP2 | |
| SCHEMBL9439602 | 0.69 | SMN1; SMN2 (0.52) | KMT2AALDH1A1SMN1; SMN2MEN1USP2 | |
| SCHEMBL874038 | 0.69 | NAMPT (0.39) | KMT2AALDH1A1SMN1; SMN2MEN1USP2 | |
| SCHEMBL2419529 | 0.68 | NPC1 (0.53) | KMT2AALDH1A1SMN1; SMN2MEN1NPC1 | |
| SCHEMBL17809069 | 0.68 | KMT2A (0.56) | RECQLTSHRKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL17809067 | 0.68 | KMT2A (0.56) | RECQLTSHRKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL17809066 | 0.68 | KMT2A (0.56) | RECQLTSHRKMT2AALDH1A1SMN1; SMN2 | |
| SCHEMBL2332283 | 0.66 | L3MBTL1 (0.60) | KMT2ASMN1; SMN2MEN1LMNAKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2619184-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | The Regents of the University of Michigan (US) | 2013-07-31 | — | — | EP | disclosed |
| WO-2012040527-A2 | DEUBIQUITINASE INHIBITORS AND METHODS FOR USE OF THE SAME | THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) | 2012-03-29 | — | — | WO | disclosed |